Systemic responses following brain injuries and inflammatory process activation induced by a neurotoxin of Androctonus scorpion venom

Neuroimmunomodulation
Zahida Taibi-DjennahFatima Laraba-Djebari

Abstract

Kaliotoxin 2 (KTX2), a neurotoxin isolated from Androctonus australis hector scorpion venom, presents a high affinity with the voltage-gated potassium channels. The targets of KTX2 in the brain and its toxic effects on the cerebral cortex have been extensively studied; however, its deleterious systemic effects on other organ systems have not yet been investigated. Inflammatory response induced by KTX2 is supported by cytokine release which could provoke multiple organ dysfunction and diverse biological disorders in mammals. The possibility that inflammatory response and brain injuries induced by KTX2 may lead to functional disturbances, e.g. in the pancreas and the liver, were investigated. The contribution of IL-6 and TNF-α to the modulation of pathophysiological effects induced by KTX2 was also tested. NMRI mice were injected by the intracerebroventricular route with a sublethal dose of KTX2 or saline solution. Inflammatory response and oxidative stress were assessed in sera and tissue homogenates. Biomarkers of pancreatic and hepatic functions and the correlation with tissue damage in the brain, liver and pancreas were also analyzed. The obtained results revealed that KTX2 injection induced an inflammatory process activation...Continue Reading

Citations

Dec 3, 2015·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Priscila C LimaEliane C Arantes
Jun 9, 2016·Journal of Biochemical and Molecular Toxicology·Amina Ladjel-MendilFatima Laraba-Djebari
Dec 14, 2016·Experimental and Molecular Pathology·Amina SifiFatima Laraba-Djebari
Aug 8, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zahida Taibi-DjennahFatima Laraba-Djebari
Jan 27, 2019·Toxins·Marie-France Martin-EauclairePierre E Bougis
Apr 8, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nesrine SifiFatima Laraba-Djebari

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