Systemic retinoids for treatment of recalcitrant IgA pemphigus

Orphanet Journal of Rare Diseases
Franziska SchauerDimitra Kiritsi

Abstract

IgA pemphigus is an exceedingly rare autoimmune blistering disorder, caused by IgA autoantibodies against desmosomal proteins. No treatment option has been found to be universally effective. The disease is often recalcitrant to oral steroids and immunosuppressants. Here, we describe the use of systemic retinoids for the treatment of recalcitrant IgA pemphigus in 3 cases. Although the use of acitretin has been reported before, we present for the first time the positive effects of alitretinoin in treatment of 2 patients with IgA pemphigus. Besides hyperlipoproteinaemia requiring use of hypolipidemic agents in one case, alitretinoin was well-tolerated and has generally a more favorable side effect spectrum than immunosuppressants.

References

Jun 18, 2011·Clinics in Dermatology·Daisuke TsurutaTakashi Hashimoto
Dec 10, 2013·Annales de dermatologie et de vénéréologie·A BellissenP Modiano
Dec 21, 2013·Journal of the American Academy of Dermatology·Ana Carulina L MorenoCelina W Maruta
Mar 8, 2014·The British Journal of Dermatology·S GellerE Sprecher
Jul 21, 2016·Drugs·Hannah A Blair, Lesley J Scott
Apr 27, 2017·JAMA Dermatology·Dimitra KiritsiJohannes S Kern

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