Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.

Scientific Reports
Benjamin DehayErwan Bezard

Abstract

Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.

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Citations

Apr 17, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pavitra S RamachandranBeverly L Davidson
Jul 3, 2015·Neurobiology of Learning and Memory·Sandrine CamusErwan Bezard
Jun 12, 2014·Frontiers in Molecular Neuroscience·Mathieu BourdenxBenjamin Dehay
Oct 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joana SaraivaLuis Pereira de Almeida
Aug 2, 2018·Human Gene Therapy Methods·Lucie Chansel-DebordeauxBenjamin Dehay
Jun 28, 2019·Gene Therapy·Rithu PattaliXue-Jun Li
Jun 29, 2018·Molecular Autism·Matthew BengerNicholas D Mazarakis
May 31, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Fares BassilPierre-Olivier Fernagut
Apr 25, 2019·Animal Models and Experimental Medicine·Lucie Chansel-Debordeaux, Erwan Bezard
Nov 18, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Tiago F OuteiroAngela M Cenci
Dec 21, 2019·Journal of Neuroscience Methods·Erwan Bezard
Feb 27, 2021·Molecular Medicine·Theodora NtetsikaIoanna Markaki
Jul 25, 2020·Neurologic Clinics·Megan A Waldrop, Bakri H Elsheikh

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Methods Mentioned

BETA
transgenic
transfection

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