Systemic sclerosis: a systematic review on therapeutic management from 2011 to 2014

Current Opinion in Rheumatology
Amber Young, Dinesh Khanna

Abstract

To review pharmacologic and nonpharmacologic therapies in the treatment of systemic sclerosis (SSc) from 2011 to 2014 through a systematic review. Our systematic review identifies randomized controlled trials, meta-analyses, systematic reviews, case series, and observational studies which support organ-based therapy with known immunosuppressive agents, novel agents, and hematopoietic stem cell transplantation, and also includes nonpharmacologic therapies improving visceral and physical function. SSc is an orphan autoimmune disorder with significant morbidity and mortality. Although there has been significant progress over the years in therapeutic options for SSc, the mainstays of treatment are organ-based and primarily symptom management. Our systematic review of the last 4 years of treatment emphasizes known treatment strategies already in practice, but also identifies new therapeutic approaches with additional biologic agents and hematopoietic stem cell transplantation.

Associated Clinical Trials

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Citations

Mar 5, 2016·Current Rheumatology Reports·Femke C C van Rhijn-BrouwerJacob M van Laar
Jan 4, 2017·The Journal of Allergy and Clinical Immunology·Elena E PerezMark Ballow
Dec 13, 2017·Oncotarget·Ines BaroneStefania Catalano
Jul 17, 2019·Arthritis Care & Research·Daniel SumptonAllison Tong
Feb 28, 2019·BioMed Research International·Andrea Sierra-SepúlvedaTatiana S Rodríguez-Reyna
Dec 27, 2016·Current Treatment Options in Rheumatology·Amber YoungDinesh Khanna
May 24, 2018·Nature Reviews. Rheumatology·Peter J WermuthSergio A Jimenez
Nov 6, 2018·Frontiers in Immunology·Nicoletta Del PapaAntonina Minniti
May 12, 2019·Internal and Emergency Medicine·Tim MontriefBrit Long
Jan 12, 2021·Clinical Rheumatology·Sasimon BorrirukwisitsakWanrachada Katchamart
Jul 23, 2018·Pediatric Clinics of North America·Suzanne C Li

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