Systemic sclerosis and pregnancy

La Revue de médecine interne
L Josselin-MahrJ Cabane

Abstract

Pregnancy in women diagnosed with systemic sclerosis is an infrequent situation with a generally favourable outcome according to the most recent studies. Women with systemic sclerosis who wish to become pregnant should obtain preconception counselling in order to withdraw teratogenic drugs and to carefully assess the disease activity. Severe organ impairment, early diffuse systemic sclerosis and pulmonary hypertension ought to discourage patients from pregnancy, as these situations are at high risk of complications for both mother and fetus during pregnancy and puerperium. During pregnancy, the most frequent maternal complication is worsening of gastroesophageal reflux, and the most severe complications are renal crisis and flaring arterial pulmonary hypertension. Angiotensin converting enzyme inhibitors are indicated at any stage of the pregnancy if renal crisis is suspected. Adverse obstetric outcomes are dominated by prematurity which may be the consequence of intra-uterine growth restriction or preeclampsia. Those complications might account for systemic sclerosis-associated vasculopathy, or for the presence of antiphospholipid antibodies. Patients with a previous history of placental insufficiency might benefit from treatm...Continue Reading

References

Aug 1, 1990·Arthritis and Rheumatism·L E KahlV D Steen
Feb 1, 1989·Arthritis and Rheumatism·V D SteenT A Medsger
Dec 15, 1985·American Journal of Obstetrics and Gynecology·M MooreR P Jacobs
Jan 1, 1988·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P Altieri, J S Cameron
Apr 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V S Lim
Dec 16, 1998·Gynecologic and Obstetric Investigation·M NakatsukaT Kudo
Dec 29, 1998·Human Pathology·B J DossF Qureshi
Apr 22, 1999·Arthritis and Rheumatism·V D Steen, T A Medsger
Jul 2, 1999·Obstetrics and Gynecology·V D Steen
Aug 8, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Mikiya NakatsukaTakafumi Kudo
Mar 15, 2003·Scandinavian Journal of Rheumatology·C C MokL Chow
Jul 5, 2003·Rheumatic Diseases Clinics of North America·Virginia D Steen
Jan 14, 2004·The Korean Journal of Internal Medicine·Kyu-Hyun ChoJung-Yoon Choe
May 14, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A-S BatsB Carbonne
Sep 25, 2004·Critical Care Clinics·Rubin CohenLinda S Efferen
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·K A ChinJ B Weaver
May 15, 2007·Rheumatic Diseases Clinics of North America·Virginia D Steen
Jun 25, 2008·Rheumatology·I MiniatiM Matucci-Cerinic
Sep 17, 2008·Rheumatology·M Trojanowska
Jan 17, 2009·European Heart Journal·Elisabeth BédardMichael A Gatzoulis
May 6, 2009·Annals of Internal Medicine·Tracy WolffUNKNOWN U.S. Preventive Services Task Force
Jun 11, 2009·Physiology·Alice WangS Ananth Karumanchi
Jun 17, 2009·American Journal of Reproductive Immunology : AJRI·Shrimati Shetty, Kanjaksha Ghosh
Sep 18, 2009·Annals of the New York Academy of Sciences·Anna Franca MiliaMarco Matucci-Cerinic

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Citations

Jan 24, 2015·Seminars in Arthritis and Rheumatism·Nilanjana BoseSoumya Chatterjee

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