Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality?

Rheumatology International
Sara SimeoniClaudio Lunardi

Abstract

We describe the case of a 59 year old man with systemic sclerosis and superficial siderosis of the central nervous system characterized by progressive worsening of walking with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia. Ferritin and oligoclonal bands were found on lumbar puncture and Magnetic Resonance Imaging of the brain and spinal cord revealed a rim of hypointensity in T2-weighted images enveloping the surface of brain and spinal cord, typical of hemosiderosis. Neurological complications, both central and peripheral, are thought to be rare and coincidental in systemic sclerosis; however over the past decade, some authors have reported a high incidence (up to 40%) of neurological involvement in the disease. In this report we consider the hypothesis that superficial siderosis may be a direct complication of systemic sclerosis. To our knowledge, this case represents the first description of superficial siderosis in a patient with systemic sclerosis.

References

Dec 1, 1992·Archives of Neurology·L Averbuch-HellerO Abramsky
Feb 1, 1970·Archives of Neurology·R M Gordon, A Silverstein
Aug 1, 1995·Brain : a Journal of Neurology·J M FearnleyP Rudge
Nov 1, 1993·Annals of Neurology·A H KoeppenR E Thach
Nov 1, 1995·British Journal of Rheumatology·A L Herrick
Oct 26, 1999·Neurology·M MascalchiC A Tassinari
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·J StoneM H Johnson
Jan 27, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·A MessoriU Salvolini

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Citations

Jul 6, 2013·Seminars in Arthritis and Rheumatism·Tiago Nardi AmaralSimone Appenzeller
Feb 23, 2018·Clinical Neuroradiology·Matthew BowerNicolas Phielipp
Jan 7, 2020·Clinical Rheumatology·Eman M KhedrDaniel E Furst

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