Systemic Sclerosis Pathogenesis and Emerging Therapies, beyond the Fibroblast

BioMed Research International
Andrea Sierra-SepúlvedaTatiana S Rodríguez-Reyna

Abstract

Systemic sclerosis (SSc) is a complex rheumatologic autoimmune disease in which inflammation, fibrosis, and vasculopathy share several pathogenic pathways that lead to skin and internal organ damage. Recent findings regarding the participation and interaction of the innate and acquired immune system have led to a better understanding of the pathogenesis of the disease and to the identification of new therapeutic targets, many of which have been tested in preclinical and clinical trials with varying results. In this manuscript, we review the state of the art of the pathogenesis of this disease and discuss the main therapeutic targets related to each pathogenic mechanism that have been discovered so far.

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Citations

Dec 28, 2019·Microorganisms·Elisabetta CaselliClodoveo Ferri
Jul 18, 2020·Expert Opinion on Pharmacotherapy·Zsuzsanna H McMahan, Elizabeth R Volkmann
Oct 3, 2020·Inflammopharmacology·Alireza HejratiParisa Zafari
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Apr 4, 2021·International Journal of Molecular Sciences·Hee Jin ParkSang-Il Lee
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Aug 5, 2021·Journal of Cell Communication and Signaling·Anastasiya MuntyanuElena Netchiporouk
Jan 16, 2022·Clinical Reviews in Allergy & Immunology·Xiufen ZhuangYanhong Wu
Jan 25, 2022·Experimental and Therapeutic Medicine·Carmen BobeicaLaura Gheuca-Solovastru

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Clinical Trials Mentioned

NCT02036970
NCT02657356

Software Mentioned

CATALYST
PATENT
SENSCIS
LARIAT
EULAR

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