Systemic Sclerosis Trial Design Moving Forward

Journal of Scleroderma and Related Disorders
Sindhu R JohnsonDaniel E Furst

Abstract

The 2013 ACR-EULAR classification criteria for systemic sclerosis (SSc) have shifted the construct of SSc. The new reality is that patients recruited for trials may not be so severe and not so advanced. We can now look for therapeutics that might stop disease evolution and/or prevent organ involvement. This article highlights recent advances in research methodology, and broadens the potential range of design and analytic considerations when planning a SSc trial.

References

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Mar 27, 2002·International Journal of Epidemiology·Diana R ElbourneAndy Vail
Sep 11, 2002·Journal of General Internal Medicine·Scott D HalpernDavid A Asch
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Sep 26, 2007·Annals of the Rheumatic Diseases·D KhannaUNKNOWN Scleroderma Clinical Trials Consortium co-authors
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Dec 2, 2008·The Journal of Rheumatology·Sindhu R JohnsonGeorge A Tomlinson
Sep 1, 2009·Journal of Clinical Epidemiology·Sindhu R JohnsonBrian M Feldman
Nov 28, 2012·Annals of the Rheumatic Diseases·Marco Matucci-CerinicSerena Guiducci

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Citations

Jul 17, 2018·The Journal of Rheumatology·Samar AlharbiSindhu R Johnson
Jun 23, 2019·Annals of the Rheumatic Diseases·Mike BeckerUNKNOWN EUSTAR Collaborators (numerical order of centres)
Nov 8, 2018·RMD Open·Vanessa SmithMarco Matucci-Cerinic
Jul 18, 2020·Expert Opinion on Pharmacotherapy·Zsuzsanna H McMahan, Elizabeth R Volkmann
Oct 11, 2017·Scandinavian Journal of Rheumatology·S R JohnsonJ E Pope
Mar 3, 2019·The Journal of Rheumatology·Haifa Al-SheikhSindhu R Johnson
Apr 4, 2019·Arthritis Research & Therapy·DeAnna Baker FrostCarol Feghali-Bostwick
Sep 30, 2017·Current Opinion in Rheumatology·Sindhu R Johnson
Apr 7, 2019·Nature Reviews. Rheumatology·Gabriela KaniaOliver Distler
Mar 16, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Natalie K KozijSindhu R Johnson
Jun 12, 2020·Therapeutic Advances in Musculoskeletal Disease·Bianca Saveria FiorettoMarco Matucci-Cerinic
Dec 5, 2020·Modern Rheumatology·Valentin DichevVictoria Stepan Sarafian
Mar 1, 2021·Arthritis Research & Therapy·DeAnna Baker FrostCarol Feghali-Bostwick
May 10, 2021·Best Practice & Research. Clinical Rheumatology·Daniel EnnisSindhu R Johnson
Aug 12, 2021·Therapeutic Advances in Musculoskeletal Disease·Masataka KuwanaAlbert Selva-O'Callaghan
Jul 3, 2021·The Journal of Rheumatology·Bader A AlMehmadiSindhu R Johnson

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Clinical Trials Mentioned

NCT00883129
NCT01532869

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