Abstract
To investigate the associations of serum amyloid A (SAA) protein and soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) with diabetic retinopathy (DR) in Hispanics. Prospective, nonrandomized, cross-sectional, family-based observational cohort study. A total of 473 Hispanic type II diabetic subjects in families ascertained via proband with DR. Levels of SAA, sTNF-R1, and sTNF-R2 were measured with enzyme-linked immunosorbent assay. Diabetic retinopathy was assessed by fundus photography and graded using modified Airlie House classification. Levels of SAA, sTNF-R1, and sTNF-R2 to severity of DR with and without covariates. A direct association of sTNF-R1 (2.37±0.13, 2.15±0.09, 3.09±0.24, 3.25±0.46, 5.02±0.61 ng/ml; P < 0.0001) and sTNF-R2 (6.04±0.20, 6.25±0.52, 7.96±0.70, 8.14±1.13, 14.83±1.68 ng/ml; P < 0.0001) was found for no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR, respectively. These associations remained significant after adjusting for age, gender, body mass index, glycosylated hemoglobin, diabetes duration, systolic blood pressure, and serum creatinine (P < 0.0001 for sTNF-R1 and P=0.0004 for sTNF-R2). A similar pattern was observed when we adjusted for urin...Continue Reading
References
May 1, 1991·Ophthalmology
Dec 1, 1994·Clinical Biochemistry·Y KumonK Hashimoto
Jan 1, 1993·Science·G S HotamisligilB M Spiegelman
Apr 19, 1996·The Journal of Biological Chemistry·A E MedvedevA Sundan
Aug 14, 1998·Diabetes Care·M I HarrisD D Byrd-Holt
Oct 29, 1998·Diabetes·J M Fernández-RealC Richart
Apr 8, 1999·Clinical and Experimental Immunology·G A LimbJ Shilling
Jul 6, 2000·Trends in Endocrinology and Metabolism : TEM·D E Moller
Sep 6, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·A HutchinsonA Booth
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D FukumuraR K Jain
Jun 26, 2001·Diabetes Care·S K WestUNKNOWN Proyecto VER
Apr 14, 2004·Archives of Ophthalmology·Monique S RoyJohn H Kempen
Oct 27, 2005·Investigative Ophthalmology & Visual Science·Annal D MelethEmily Y Chew
Sep 20, 2006·Archives of Internal Medicine·Hubertus HimmerichThomas Pollmächer
Aug 23, 2007·JAMA : the Journal of the American Medical Association·Quresh MohamedTien Y Wong
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Ronald B Goldberg
Jun 25, 2009·Diabetes Care·Thanh T NguyenTien Y Wong
Sep 16, 2009·Archives of Ophthalmology·Barbara E K KleinRonald Klein
Feb 9, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yulan ZhaoChew-Kiat Heng
Feb 13, 2010·American Journal of Ophthalmology·Rohit VarmaUNKNOWN Los Angeles Latino Eye Study Group
Jun 29, 2010·Lancet·Ning CheungTien Yin Wong
Aug 12, 2010·JAMA : the Journal of the American Medical Association·Xinzhi ZhangRonald Klein
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association
Citations
Nov 10, 2013·JAMA Ophthalmology·Jane Z KuoJerome I Rotter
Apr 9, 2013·Human Molecular Genetics·Wayne H-H SheuYii-Der I Chen
Nov 22, 2013·Mediators of Inflammation·C CostagliolaF Semeraro
Dec 3, 2014·BMJ Open Diabetes Research & Care·Jane Z KuoEli Ipp
Jan 15, 2013·Journal of Biochemical and Molecular Toxicology·Kathryn A BaileyRebecca C Fry
Dec 3, 2014·Journal of Diabetes and Its Complications·Hussein A RajabUNKNOWN DCCT/EDIC Group of Investigators
Nov 28, 2018·Journal of Cellular Physiology·Rana ShafabakhshZatollah Asemi
Nov 30, 2018·Diabetes·Samuela PollackLucia Sobrin
Dec 14, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nurul Hafizah Amil-BangsaAhmad Rohi Ghazali
Sep 28, 2017·Diabetes·Lucia SobrinChing-Yu Cheng
Jun 25, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Li-Hsin ChangLiang-Yu Lin
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Li-Hsin ChangLiang-Yu Lin
Apr 2, 2021·Frontiers in Endocrinology·Yixin NiuQing Su
Jun 25, 2021·American Journal of Ophthalmology·Lucia SobrinAyellet V Segrè
Oct 29, 2021·Indian Journal of Ophthalmology·Abhishek SheemarPradeep Venkatesh