Systemic soluble tumor necrosis factor receptors 1 and 2 are associated with severity of diabetic retinopathy in Hispanics.

Ophthalmology
Jane Z KuoYii-Der Ida Chen

Abstract

To investigate the associations of serum amyloid A (SAA) protein and soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) with diabetic retinopathy (DR) in Hispanics. Prospective, nonrandomized, cross-sectional, family-based observational cohort study. A total of 473 Hispanic type II diabetic subjects in families ascertained via proband with DR. Levels of SAA, sTNF-R1, and sTNF-R2 were measured with enzyme-linked immunosorbent assay. Diabetic retinopathy was assessed by fundus photography and graded using modified Airlie House classification. Levels of SAA, sTNF-R1, and sTNF-R2 to severity of DR with and without covariates. A direct association of sTNF-R1 (2.37±0.13, 2.15±0.09, 3.09±0.24, 3.25±0.46, 5.02±0.61 ng/ml; P < 0.0001) and sTNF-R2 (6.04±0.20, 6.25±0.52, 7.96±0.70, 8.14±1.13, 14.83±1.68 ng/ml; P < 0.0001) was found for no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR, respectively. These associations remained significant after adjusting for age, gender, body mass index, glycosylated hemoglobin, diabetes duration, systolic blood pressure, and serum creatinine (P < 0.0001 for sTNF-R1 and P=0.0004 for sTNF-R2). A similar pattern was observed when we adjusted for urin...Continue Reading

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Citations

Nov 10, 2013·JAMA Ophthalmology·Jane Z KuoJerome I Rotter
Apr 9, 2013·Human Molecular Genetics·Wayne H-H SheuYii-Der I Chen
Nov 22, 2013·Mediators of Inflammation·C CostagliolaF Semeraro
Jan 15, 2013·Journal of Biochemical and Molecular Toxicology·Kathryn A BaileyRebecca C Fry
Dec 3, 2014·Journal of Diabetes and Its Complications·Hussein A RajabUNKNOWN DCCT/EDIC Group of Investigators
Nov 28, 2018·Journal of Cellular Physiology·Rana ShafabakhshZatollah Asemi
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Jun 25, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Li-Hsin ChangLiang-Yu Lin
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Li-Hsin ChangLiang-Yu Lin
Jun 25, 2021·American Journal of Ophthalmology·Lucia SobrinAyellet V Segrè

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