Systemic therapy of cutaneous T-cell lymphoma (CTCL)

Chinese Clinical Oncology
Onder AlpdoganPierluigi Porcu

Abstract

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous and relatively rare family of extranodal non-Hodgkin's lymphomas (NHL) that are primarily localized to the skin. Most patients present with cutaneous patches, plaques, tumors, more rarely with erythroderma. The type of skin lesions and the surface extent of skin involvement, as well as the presence of extracutaneous disease, are the most important prognostic factors in patients with CTCL. Patients with early-stage disease can be effectively treated with skin-directed therapies only. As the disease progresses, systemic therapy often becomes necessary. In this review, we will provide an overview of the systemic treatment options for CTCL, including mechanism of action, efficacy, side effects, and discuss current principles for rational combination therapy and sequential use. Systemic therapy strategies have been evolving with the recent FDA approval of new monoclonal antibodies such as brentuximab vedotin and mogamulizumab to established drugs, such as retinoids, interferons (IFNs), and HDAC inhibitors. Numerous new agents are currently being studied in clinical trials. Identifying the genetic, molecular, and immunologic features of CTCL that are associated with disease progr...Continue Reading

Citations

Feb 12, 2020·International Journal of Dermatology·Ellen M S XerfanAnamaria S Facina
Feb 29, 2020·Molecular Oncology·Haoyu WangZhirui Wang
May 20, 2020·International Journal of Molecular Sciences·Przemysław KoźmińskiEwa Gniazdowska
May 5, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Vasiliki NikolaouSabine-Elke Kruger-Krasagakis
Dec 17, 2019·Therapeutic Advances in Medical Oncology·Catalina Silva-HirschbergAxel H Schönthal
Oct 24, 2020·British Journal of Haematology·Julia J ScarisbrickPablo L Ortiz-Romero
Mar 27, 2021·American Journal of Clinical Pathology·Antonio TravaglinoMassimo Mascolo
Apr 24, 2021·Expert Review of Clinical Immunology·Antreas PavlidisEvangelia Papadavid
Jun 1, 2021·Anais Brasileiros De Dermatologia·José Antonio SanchesJuliana Pereira
Aug 28, 2021·Nature Reviews. Disease Primers·Reinhard DummerEgle Ramelyte
Sep 18, 2021·Clinical Journal of Oncology Nursing·Karla V Ow, Jeannine M Brant
Jul 22, 2020·International Archives of Allergy and Immunology·Malgorzata BobrowiczEmmanuella Guenova

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