PMID: 589572Dec 1, 1977

Systemic thermotherapy: description of a method and physiologic tolerance in clinical subjects

Cancer
J M LarkinP J Clark

Abstract

A safe, effective method of inducing total body hyperthermia to 42 degrees C (108 degrees F) has been developed and applied to clinical subjects with advanced malignancy. Physiological and biochemical parameters have been studied to determine tolerance and detect toxicity. Treatments were well tolerated with appropriate life support measures, mainly fluid and electrolyte replacement. Occasional arrhythmias and superficial cutaneous burns were the major complications. No evidence of central nervous system dysfunction was detected. Serum enzyme elevations after treatment appeared to indicate hepatic cellular injury but no clinical problems resulted. Renal, pulmonary, and hematologic parameters showed no significant changes from baseline values. Two early deaths occurred in patients with massive liver replacement with tumor and such patients may not be appropriate subjects for hyperthermia.

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Related Concepts

Cardiac Arrhythmia
Burn Injury
Edema, Cardiac
Cardiac Arrest
Hyperthermia, Local
Malignant Neoplasm of Liver
Malignant Neoplasms
Water-Electrolyte Balance

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International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
M H ProctorA Milligan
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