Abstract
In patients with left ventricular assist device (LVAD) implants, pump thrombosis is a potential life-threatening complication. In a retrospective data analysis, we compared clinical outcomes in 50 patients with HeartWare (HW) or HeartMate II implants undergoing device exchange (DEx; n = 21) or systemic thrombolysis (STL; n = 29) for pump thrombosis. Primary end-point was survival up to 90 days postintervention. Secondary end-points were the need for blood products postintervention, duration of intensive care unit stay, in-hospital stay, 90 day and 2 year therapy failure (the need for additional surgical or nonsurgical intervention because of pump thrombosis), and 2 year survival. Ninety-day survival was 89.3% in the STL group and 91.0% in the DEx group (p = 0.901). Compared with the DEx group, the average use of different blood products was lower (p < 0.001), and duration of intensive care unit stay and in-hospital stay tended to be shorter in the STL group (p values = 0.086 and 0.048, respectively). However, 90 day freedom from therapy failure was significantly lower in the STL group than in the DEx exchange group (p = 0.027) and so was 2 year freedom from therapy failure (p = 0.006). Two-year survival was comparable between g...Continue Reading
References
Jun 25, 2005·Journal of Thrombosis and Thrombolysis·Heinrich KoertkeReiner Koerfer
Jan 22, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Igor D Gregoric
May 14, 2009·Vascular Health and Risk Management·Giovanni MelandriAngelo Branzi
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Subha V RamanBenjamin Sun
Jul 27, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Lech PaluszkiewiczGero Tenderich
Feb 1, 2011·The Journal of Thoracic and Cardiovascular Surgery·Michael S KiernanNavin K Kapur
Feb 23, 2011·Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular·Luiz Felipe Pinho Moreira, Anderson Benício
Aug 23, 2011·Echocardiography·Lech PaluszkiewiczJan Gummert
Jan 28, 2012·Circulation. Heart Failure·Soon J ParkUNKNOWN HeartMate II Clinical Investigators
Jun 22, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gilbert H L TangAnelechi C Anyanwu
Jul 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·James K KirklinJames B Young
Aug 14, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Takeyoshi OtaYoshifumi Naka
Nov 26, 2013·Journal of Cardiac Surgery·Carlo R BartoliJohn A Kern
Dec 21, 2013·Cerebrovascular Diseases·L D ViegasJ M Ferro
Dec 24, 2013·Journal of Cardiac Failure·Kelly SchlendorfJoseph G Rogers
Jan 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinMarissa A Miller
Jan 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Samer S NajjarUNKNOWN HVAD Bridge to Transplant ADVANCE Trial Investigators
May 27, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Jun 21, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Elizabeth HohnerMichael P Moranville
Citations
Mar 30, 2017·Expert Review of Cardiovascular Therapy·Gengo SunagawaKiyotaka Fukamachi
May 4, 2017·Expert Review of Medical Devices·Luca BottaClaudio Francesco Russo
Apr 6, 2017·Journal of Cardiothoracic Surgery·Thomas KrabatschYuriy Pya
Dec 17, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Geetanjali DangLisa Baumann Kreuziger
Jan 25, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Cenk OezpekerMichiel Morshuis
Feb 15, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dominik WiedemannDaniel Zimpfer
Jan 29, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Veraprapas KittipibulRandall C Starling
Mar 20, 2020·ESC Heart Failure·Rene SchrammJan F Gummert
Dec 10, 2019·Perfusion·Carlo BanfiRaphaël Giraud
Nov 1, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Cenk OezpekerMichiel Morshuis
Nov 1, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Sotirios SpiliopoulosOtto Dapunt
Apr 13, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiroto KitaharaTakeyoshi Ota
Dec 19, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takayuki GyotenHenrik Fox
Oct 27, 2020·BioMed Research International·Tao DingJun Wen
Feb 19, 2021·The International Journal of Artificial Organs·Tyler C LewisNader Moazami
Jul 2, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Angela LortsAntonio Amodeo