Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum

The Lancet Oncology
Andrew BurroughsTim Meyer

Abstract

Hepatocellular carcinoma is the fifth most common malignant disorder and causes nearly 1 million deaths a year worldwide. A background of cirrhosis is the major risk factor, and in Asia and subSaharan Africa, cirrhosis is attributable mainly to endemic hepatitis B infection. In Europe and the USA the incidence of hepatocellular carcinoma is increasing as a result of the high prevalence of hepatitis C. The only curative treatments are surgical resection or liver transplantation, but only a few patients are eligible for these procedures. Local ablative treatments such as ethanol injection can lengthen survival in selected patients, and radiofrequency ablation also shows promise. Unfortunately, most patients are suitable only for palliative treatment because of the extent of their tumour or background liver disease or both. For these patients, a wide range of therapeutic interventions have been assessed, including transarterial embolisation (with or without chemotherapy), hormone therapy with antioestrogens and androgens, octreotide, interferon, and both arterial and systemic chemotherapy, of which only chemoembolisation improves survival over symptomatic care. Tamoxifen is ineffective, and there are insufficient randomised data t...Continue Reading

References

Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S OkadaK Aoki
Aug 1, 1993·Japanese Journal of Cancer Research : Gann·M KonishiN Hattori
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R TakamoriL Wong
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetG J Gores
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S TodoT Shimamura
Mar 27, 2001·Transplantation Proceedings·L ToméL Furtado
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F P SarasinA Hadengue
Jun 19, 2001·Mutation Research·M Kartalou, J M Essigmann
Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerW R Kim
Apr 6, 2002·Digestive Diseases·G Treiber
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Man-Fung YuenBenjamin Chun-Yu Wong
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ernesto P Molmenti, Goran B Klintmalm
Oct 3, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts

❮ Previous
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Citations

Dec 12, 2012·Cardiovascular and Interventional Radiology·Sylvain FavelierBoris Guiu
Feb 29, 2008·Investigational New Drugs·Allen L CohnLina Asmar
Nov 30, 2005·Current Treatment Options in Gastroenterology·Aaron Shields, K Rajender Reddy
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Andrew Burroughs, Dimitrios Samonakis
Feb 5, 2009·Nature Clinical Practice. Gastroenterology & Hepatology·Giuseppe CabibboAntonio Craxì
Dec 1, 2012·Anti-cancer Drugs·Massimiliano BerrettaUmberto Tirelli
Jul 26, 2006·BMC Cancer·Ciro GalloUNKNOWN CLIP (Cancer of the Liver Italian Programme) Investigators
Mar 28, 2008·BMC Cancer·Matthias M DollingerWolfgang E Fleig
Aug 6, 2008·World Journal of Gastroenterology : WJG·Adam Bartlett, Nigel Heaton
Jun 3, 2011·World Journal of Gastroenterology : WJG·Nicolas WillietJulien Taieb
Jun 27, 2013·World Journal of Gastroenterology : WJG·Li-Zhi NiuKe-Cheng Xu
Apr 4, 2014·World Journal of Gastroenterology : WJG·Emmanuel A TsochatzisAndrew K Burroughs
Oct 24, 2013·Translational Oncology·Takuji TorimuraMichio Sata
Mar 31, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Thomas DecaensChristophe Duvoux
Jan 28, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-H ZhongG-B Wu
Jun 22, 2011·Clinics in Liver Disease·Marcelo Guimaraes, Renan Uflacker
Apr 2, 2009·Biochimica Et Biophysica Acta·Patrizia BottoniRoberto Scatena
Mar 22, 2016·Hepatic Oncology·Josiah Cox, Steven Weinman
Mar 14, 2007·The American Journal of Medicine·Sameer Parikh, David Hyman
Apr 17, 2015·Scientific Reports·Meng-Tzu WengJin-Chuan Sheu
Apr 12, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Patrizia Burra, Michael R Lucey
Oct 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Rasool AljabiriAndrew K Burroughs
Apr 1, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Gunnar SöderdahlBo-Göran Ericzon
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Alisan KahramanAli Canbay
Sep 3, 2011·Alimentary Pharmacology & Therapeutics·M PinterM Peck-Radosavljevic
Jul 28, 2009·International Journal of Cancer. Journal International Du Cancer·Tongsen ZhengLianxin Liu
Nov 20, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shigeki NakagawaHideo Baba
Dec 2, 2009·The American Journal of Pathology·Takumi KawaguchiMichio Sata

❮ Previous
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