Systemic treatments for noninfectious vitreous inflammation

Mediators of Inflammation
Angela JiangJohn B Christoforidis

Abstract

Vitreous inflammation, or vitritis, may result from many causes, including both infectious and noninfectious, including rheumatologic and autoimmune processes. Vitritis is commonly vision threatening and has serious sequelae. Treatment is frequently challenging, but, today, there are multiple methods of systemic treatment for vitritis. These categories include corticosteroids, antimetabolites, alkylating agents, T-cell inhibitors/calcineurin inhibitors, and biologic agents. These treatment categories were reviewed last year, but, even over the course of just a year, many therapies have made progress, as we have learned more about their indications and efficacy. We discuss here discoveries made over the past year on both existing and new drugs, as well as reviewing mechanisms of action, clinical dosages, specific conditions that are treated, adverse effects, and usual course of treatment for each class of therapy.

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Citations

May 16, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Fabio GasparinFrancisco Max Damico
Aug 4, 2016·Expert Opinion on Drug Delivery·Raghu Raj Thakur SinghRyan F Donnelly
Jan 23, 2021·Medicina clínica·Luis Castilla-GuerraErnesto Carmona-González

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