Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases.

Nature Biomedical Engineering
Zongmin ZhaoSamir Mitragotri

Abstract

Eliciting immune responses against primary tumours is hampered by their immunosuppressive microenvironment and by the greater inaccessibility of deeper intratumoural cells. However, metastatic tumour cells are exposed to highly perfused and immunoactive organs, such as the lungs. Here, by taking advantage of the preferential colocalization of intravenously administered erythrocytes with metastases in the lungs, we show that treatment with chemokine-encapsulating nanoparticles that are non-covalently anchored onto the surface of injected erythrocytes results in local and systemic tumour suppression in mouse models of lung metastasis. Such erythrocyte-anchored systemic immunotherapy led to the infiltration of effector immune cells into the lungs, in situ immunization without the need for exogenous antigens, inhibition of the progression of lung metastasis, and significantly extended animal survival and systemic immunity that suppressed the growth of distant tumours after rechallenge. Erythrocyte-mediated systemic immunotherapy may represent a general and potent strategy for cancer vaccination.

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Citations

Feb 22, 2021·Drug Delivery and Translational Research·Anvay UkidveSamir Mitragotri
Mar 17, 2021·Molecular Therapy. Methods & Clinical Development·Magnus A G HoffmannPamela J Bjorkman
May 19, 2021·Nature Biomedical Engineering·Pengcheng Zhang, Yaping Li
Jul 24, 2021·Cellular and Molecular Bioengineering·Jensen N AmensPinar Zorlutuna

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