Systemic vasculitis: a cause of indeterminate intestinal inflammation

Journal of Pediatric Gastroenterology and Nutrition
P A BroganM J Dillon

Abstract

Indeterminate intestinal inflammation may result from a variety of inflammatory conditions in addition to ulcerative colitis and Crohn disease. The primary systemic vasculitides may present with intestinal inflammation and an indeterminate colitis. We set out to describe a series of children with primary systemic vasculitis who initially presented with clinical features suggestive of inflammatory bowel disease (IBD) to establish criteria that might help discriminate between IBD and primary systemic vasculitis. Ten children (6 boys, median age at presentation 8.9 years, range 0.9-14.5 years) satisfied inclusion criteria. All had abdominal pain, weight loss, diarrhea (6 of 10 bloody) and laboratory evidence of a severe acute phase response. Extraintestinal clinical features included vasculitic rash, renal impairment, myalgia, testicular pain and polyarthritis. Endoscopy showed vascular changes or other macroscopic findings suggestive of vasculitis in 5 of 10 patients. Gut histology revealed indeterminate chronic inflammatory mucosal changes and one patient with small artery fibrinoid necrosis in the submucosal vessels. Extraintestinal biopsy was performed in 6 patients and had a higher yield for the demonstration of vasculitis th...Continue Reading

References

Jul 1, 1975·Radiology·A J Nicks, F Hughes
Feb 1, 1979·Archives of Dermatology·J P Callen
May 1, 1975·The American Journal of Digestive Diseases·J A Forrest, D J Shearman
Aug 1, 1990·The Journal of Allergy and Clinical Immunology·A SaxonS Targan
Sep 1, 1988·Arthritis and Rheumatism·D A AlbertM D Silverstein
May 15, 1987·American Journal of Ophthalmology·J S DukerL Brooks
May 1, 1986·Neurology·J NelsonS S Schochet
Apr 1, 1985·Arthritis and Rheumatism·D D GladmanS Kulkarni
May 1, 1985·Southern Medical Journal·D SargentR P Fairman
Jul 1, 1985·Journal of the Royal Society of Medicine·D N SlaterG Reilly
Sep 1, 1985·Clinical Rheumatology·J C SpeiserJ Zuckner
Oct 12, 1974·British Medical Journal·F J WackersJ Vreeken
Jan 1, 1966·The American Journal of Digestive Diseases·M Akbarian
May 1, 1967·The British Journal of Surgery·C L Colton, T J Butler
Mar 1, 1972·Southern Medical Journal·R C Hunsicker, P M James
Dec 19, 1968·The New England Journal of Medicine·J I IsenbergV Rosen
May 1, 1995·Archives of Disease in Childhood·O P Smith, I M Hann
Dec 1, 1994·Archives of Disease in Childhood·H R JenkinsG M Vujanic
Mar 1, 1995·Postgraduate Medical Journal·M Garcia-DiazJ C Bureo
Apr 1, 1993·Journal of Pediatric Surgery·H Z GündoğduA Hiçsönmez
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Jul 1, 1996·Journal of Internal Medicine·B DahlanderB U Hansen
May 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·R M BeattieJ A Walker-Smith
May 1, 1997·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U K SchlehaiderL Kowalzick
Nov 26, 1997·Archives of Disease in Childhood·M C Nash, M J Dillon
May 26, 1998·Journal of Clinical Gastroenterology·N EliasJ H Boss
Jul 1, 1998·The American Journal of Gastroenterology·M H Kay, R Wyllie
Aug 22, 2000·Archives of Disease in Childhood·P A Brogan, M J Dillon
Oct 12, 2000·American Journal of Ophthalmology·J F SalmonP Frith
Dec 21, 2000·Current Rheumatology Reports·P A Brogan, M J Dillon
Mar 21, 2002·The American Journal of Medicine·Stuart M LevineJohn H Stone
Apr 17, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Paul A BroganMichael J Dillon
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Anthony BoothDavid Jayne
Feb 24, 1949·The New England Journal of Medicine·R R LINTON, T B MALLORY

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.