Systemic zoledronate precoating of a bone graft reduces bone resorption during remodeling

Acta Orthopaedica
Magnus TägilJörgen Astrand

Abstract

Cartilage degeneration often occurs after osteosynthesis of a devascularized intermediary fragment in a joint fracture, in mosaicplasty or in whole-joint toe-to-finger transplantation. Hypothetically, the degeneration is secondary to a collapse of the transferred subchondral bone as it remodels during high mechanical load. Bisphosphonates are used to reduce resorption of necrotic bone. We tested a systemic pretreatment before harvesting the graft in order to protect the bone and cartilage against collapse and secondary arthrosis. Rats were given one zoledronate injection and bone grafts were harvested. The grafts were frozen, thawed and placed into bone chambers, and implanted into another batch of rats. Graft resorption and new bone formation was measured by histomorphometric analysis and compared with untreated grafts. In the remodeled area of the controls, the graft was almost totally resorbed and replaced by bone marrow. In the zoledronate-treated specimens, the graft remained and the graft trabeculas were lined with new bone. By histomorphometry, the total amount of bone (graft plus new bone) within the remodeled area was 16% in the zoledronate-treated grafts and 5% in the controls (p = 0.003). A bone graft can be pretreat...Continue Reading

References

Mar 1, 2002·The New England Journal of Medicine·Ian R ReidPierre J Meunier
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Citations

Mar 20, 2013·Surgical and Radiologic Anatomy : SRA·Warren M RozenEdmund W Ek
Mar 20, 2013·Surgical and Radiologic Anatomy : SRA·Warren M RozenEdmund W Ek
Dec 29, 2013·Cell and Tissue Banking·N M C MathijssenG Hannink
Apr 11, 2009·The Orthopedic Clinics of North America·Robin N GoytiaHarpal S Khanuja
Oct 18, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carol MuehlemanKoichi Masuda
Apr 12, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anna Kajsa HardingMagnus Tägil
Sep 4, 2015·The Journal of Hand Surgery·Hisao IshiiHitoshi Hirata
Jan 18, 2017·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Nicole ChengChristine Hong
Aug 26, 2020·Tissue Engineering. Part a·Marwa Y ShaheenHamdan S Alghamdi
May 2, 2009·The Journal of Bone and Joint Surgery. British Volume·F Agholme, P Aspenberg
Oct 31, 2012·The Journal of Bone and Joint Surgery. British Volume·C Y Ng, A C Watts
Jul 15, 2021·The Journal of Hand Surgery, European Volume·Danielle NizzeroJames Leong

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