Abstract
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises questions regarding their biosafety. Our aim was to evaluate whether systemically administered allogeneic MSCs modify the natural progression of precancerous lesions and whether their putative effect depends on cancer stage and/or cell dose. Oral squamous cell carcinoma (OSCC) was induced in Syrian golden hamsters by topical application of 7,12-dimethylbenz[a]anthracene in one buccal pouch. At hyperplasia, dysplasia, or papilloma stage, animals received intracardially the vehicle or 0.7 × 106, 7 × 106, or 21 × 106 allogeneic bone marrow-derived MSCs/kg. OSCC progression was assessed according to the presence of erythroplakia and leukoplakia, extent of inflammation and vascularization, and appearance, volume, and staging of tumors. Also, the homing of donor cells was studied. Precancerous lesions progressed from hyperplasia to dysplasia in 2 weeks, from dysplasia to papilloma in 3 weeks, and from papilloma to carcinoma in 4 weeks. This time course was unmodified by the systemic administrati...Continue Reading
References
Jan 1, 1992·Pharmacology & Therapeutics·E L Cavalieri, E G Rogan
Jan 1, 1988·Nutrition and Cancer·J SchwartzD Trickler
Aug 24, 1999·Journal of Cellular Physiology·P A Conget, J J Minguell
Apr 19, 2006·Journal of Cellular Biochemistry·Arnold I Caplan, James E Dennis
Apr 25, 2006·Experimental Cell Research·Ida Rasmusson
Oct 25, 2006·Transplantation·Farida DjouadDanièle Noël
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Stephen G BallCay M Kielty
Apr 11, 2008·Gene Therapy·E SpaethF Marini
Sep 12, 2008·Nature Reviews. Cancer·Jane E Visvader, Geoffrey J Lindeman
Feb 24, 2009·The Annals of Thoracic Surgery·Hirotsugu HamamotoRobert C Gorman
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fernando EzquerPaulette Conget
Apr 13, 2010·Stem Cells and Development·Araceli Valle-Prieto, Paulette A Conget
Jul 14, 2010·Cell Stem Cell·Patrick L TaylorIrving L Weissman
Aug 26, 2010·Cytotherapy·Darwin J ProckopArmand Keating
Feb 1, 2011·Stem Cells·Ann H KloppFrank Marini
Mar 2, 2011·Journal of Hepatology·Marcelo EzquerPaulette Conget
Mar 23, 2011·Molecular Medicine·Kazuhiro SuzukiYasuo Saijo
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Philippe BourinLuc Sensebé
Jan 27, 2012·Stem Cell Research & Therapy·Sara MorandoAntonio Uccelli
May 31, 2012·Stem Cells·Fernando EzquerPaulette Conget
Nov 3, 2012·JAMA : the Journal of the American Medical Association·Joshua M HareAlbert Lardo
Nov 8, 2012·PloS One·Manoj M LaluUNKNOWN Canadian Critical Care Trials Group
Feb 27, 2013·The American Journal of Pathology·Jung S Byun, Kevin Gardner
Feb 26, 2014·Thorax·Elizabeth K SageSam M Janes
Nov 14, 2014·Journal of Dental Research·L XiaM Fan
Jan 18, 2015·Experimental Biology and Medicine·David ContadorPaulette Conget
Mar 31, 2015·World Journal of Stem Cells·Martha L Arango-RodriguezPaulette Conget
Apr 14, 2016·British Journal of Hospital Medicine·Anne M Hegarty, Keith D Hunter
Jun 9, 2016·Expert Opinion on Biological Therapy·Anna HagenhoffPeter J Nelson
Nov 24, 2016·Alimentary Pharmacology & Therapeutics·C GrégoireY Beguin
Dec 13, 2016·Stem Cell Research·Flavia BrunaPaulette Conget
Jan 29, 2017·Cancer Letters·M Rita I Young
Jan 16, 2018·International Journal of Medical Sciences·Vladislav VolarevicMiodrag Stojkovic
Citations
May 22, 2019·International Journal of Molecular Sciences·Benjamin BochonGrzegorz Wystrychowski
Sep 27, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fei WangXin Geng
Mar 7, 2021·Journal of Personalized Medicine·Caroline HochheuserIlse Timmerman
Mar 27, 2021·Scientific Reports·Gina PennacchiottiFlavia Alejandra Bruna
May 28, 2021·Frontiers in Oncology·Flavia Bruna, Pablo Scodeller