PMID: 8940664Aug 1, 1996Paper

Systemically administered gonadotrophin-releasing hormone enhances copulatory behaviour in castrated, testosterone-treated hyperprolactinaemic male rats

International Journal of Andrology
E DennisonC J Meliska

Abstract

Hyperprolactinaemic male rats exhibit deficits in copulatory behaviour which can be reversed by a single injection of GnRH. We tested whether systemically administered GnRH can stimulate copulatory behaviour independently of LH-mediated increases in plasma testosterone levels. Gonadectomized, pituitary-grafted adult male Fischer 344 rats bearing implants of 5, 10 or 20 mm capsules of testosterone were administered a single injection of 500 ng GnRH or saline s.c., 30 min prior to copulation tests. Pituitary-grafted castrates displayed copulatory deficits, relative to sham-operated castrates with identical levels of testosterone replacement. Administration of 500 ng GnRH to pituitary-grafted castrates bearing 10 mm testosterone implants significantly increased the proportion of rats that mounted, intromitted and ejaculated during a 30 min test. This treatment also reduced significantly the latency of intromission and ejaculation, and increased significantly the frequency of intromission. The copulatory behaviour of the sexually unresponsive, pituitary-grafted castrates bearing 5 mm testosterone implants, or of the more sexually responsive castrates bearing 20 mm testosterone implants, was not altered significantly by GnRH injecti...Continue Reading

References

Sep 1, 1979·Biology of Reproduction·B SvareM S Smith
Mar 1, 1987·Hormones and Behavior·K J Sellers, A Bartke
Oct 1, 1982·Endocrinology·F H Bronson, C Desjardins

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Citations

Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Argiolas
Feb 5, 2010·The European Journal of Neuroscience·T A BaskervilleA J Douglas
Feb 27, 2007·Journal of Gastroenterology·Thorsten GerstnerStephan König

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