Systems analysis of dilated cardiomyopathy in the next generation sequencing era

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Magdalena Harakalova, Folkert W Asselbergs

Abstract

Dilated cardiomyopathy (DCM) is a form of severe failure of cardiac muscle caused by a long list of etiologies ranging from myocardial infarction, DNA mutations in cardiac genes, to toxics. Systems analysis integrating next-generation sequencing (NGS)-based omics approaches, such as the sequencing of DNA, RNA, and chromatin, provide valuable insights into DCM mechanisms. The outcome and interpretation of NGS methods can be affected by the localization of cardiac biopsy, level of tissue degradation, and variable ratios of different cell populations, especially in the presence of fibrosis. Heart tissue composition may even differ between sexes, or siblings carrying the same disease causing mutation. Therefore, before planning any experiments, it is important to fully appreciate the complexities of DCM, and the selection of samples suitable for given research question should be an interdisciplinary effort involving clinicians and biologists. The list of NGS omics datasets in DCM to date is short. More studies have to be performed to contribute to public data repositories and facilitate systems analysis. In addition, proper data integration is a difficult task requiring complex computational approaches. Despite these complications,...Continue Reading

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Citations

Apr 12, 2019·Current Opinion in Cardiology·Scot J Matkovich
Feb 6, 2019·Molecular Medicine Reports·Guangyong HuangWenbo Yang
Mar 4, 2021·Journal of Clinical Medicine·Arjan SammaniAnneline S J M Te Riele
Apr 1, 2021·Journal of the American Heart Association·Ricardo O Ramirez FloresJulio Saez-Rodriguez

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