Systems biology: A tool for charting the antiviral landscape

Virus Research
James R BowenMehul S Suthar

Abstract

The host antiviral programs that are initiated following viral infection form a dynamic and complex web of responses that we have collectively termed as "the antiviral landscape". Conventional approaches to studying antiviral responses have primarily used reductionist systems to assess the function of a single or a limited subset of molecules. Systems biology is a holistic approach that considers the entire system as a whole, rather than individual components or molecules. Systems biology based approaches facilitate an unbiased and comprehensive analysis of the antiviral landscape, while allowing for the discovery of emergent properties that are missed by conventional approaches. The antiviral landscape can be viewed as a hierarchy of complexity, beginning at the whole organism level and progressing downward to isolated tissues, populations of cells, and single cells. In this review, we will discuss how systems biology has been applied to better understand the antiviral landscape at each of these layers. At the organismal level, the Collaborative Cross is an invaluable genetic resource for assessing how genetic diversity influences the antiviral response. Whole tissue and isolated bulk cell transcriptomics serves as a critical ...Continue Reading

Citations

Jul 7, 2020·International Journal of Molecular Medicine·Felician StancioiuAristidis Tsatsakis
Mar 16, 2017·European Journal of Immunology·Kendra M QuickeMehul S Suthar

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Methods Mentioned

BETA
RNAseq
nucleic acid amplification
single cell sequencing
Drop-seq
ChIP-Seq
dissection

Software Mentioned

Drop
seq

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