Systems Biology Approach for Cancer Vaccine Development and Evaluation

Vaccines
Luisa CircelliLuigi Buonaguro

Abstract

Therapeutic cancer vaccines do not hold promise yet as an effective anti-cancer treatment. Lack of efficacy or poor clinical outcomes are due to several antigenic and immunological aspects that need to be addressed in order to reverse such trends and significantly improve cancer vaccines' efficacy. The newly developed high throughput technologies and computational tools are instrumental to this aim allowing the identification of more specific antigens and the comprehensive analysis of the innate and adaptive immunities. Here, we review the potentiality of systems biology in providing novel insights in the mechanisms of the action of vaccines to improve their design and effectiveness.

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Citations

Oct 5, 2016·Advances in Physiology Education·Melanie Rae Simpson
Oct 8, 2019·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jong-Myon Bae
Nov 11, 2016·Cancer Immunology, Immunotherapy : CII·Luisa CircelliLuigi Buonaguro
May 5, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Syed Aun MuhammadQiyu Zhang
Aug 8, 2017·Science Immunology·Russell E VanceDavid H Raulet
Jan 25, 2020·Journal of Translational Medicine·Angela MaurielloLuigi Buonaguro
Mar 7, 2020·Journal of Experimental & Clinical Cancer Research : CR·Maria Teresa Di MartinoMichele Caraglia

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Methods Mentioned

BETA
flow cytometry
surface plasmon resonance imaging
chips

Related Concepts

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Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

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