Systems Biology-Based Investigation of Host-Plasmodium Interactions

Trends in Parasitology
Maren L Smith, Mark P Styczynski

Abstract

Malaria is a serious, complex disease caused by parasites of the genus Plasmodium. Plasmodium parasites affect multiple tissues as they evade immune responses, replicate, sexually reproduce, and transmit between vertebrate and invertebrate hosts. The explosion of omics technologies has enabled large-scale collection of Plasmodium infection data, revealing systems-scale patterns, mechanisms of pathogenesis, and the ways that host and pathogen affect each other. Here, we provide an overview of recent efforts using systems biology approaches to study host-Plasmodium interactions and the biological themes that have emerged from these efforts. We discuss some of the challenges in using systems biology for this goal, key research efforts needed to address those issues, and promising future malaria applications of systems biology.

Citations

Apr 12, 2019·Parasite Immunology·Ann M MoormannCatherine S Forconi
Jun 27, 2019·Briefings in Functional Genomics·Mary R Galinski
May 7, 2019·Briefings in Functional Genomics·José L Ruiz, Elena Gómez-Díaz
Mar 22, 2021·Malaria Journal·Mercia RasoanoroBeza Ramasindrazana
Mar 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Min ZhouThomas Efferth
Aug 7, 2021·Pathogens·Jing-Wen HangBenoit Malleret
Aug 28, 2021·PLoS Neglected Tropical Diseases·Ohanna Cavalcanti de Lima BezerraMilton Ozório Moraes

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