Systems biology of the secretory pathway: what have we learned so far?

Biology of the Cell
Hesso Farhan

Abstract

Several RNAi screens were performed in search for regulators of the secretory pathway. These screens were performed in different organisms and cell lines and relied on different readouts. Therefore, they have only little overlap among their hits, leading to the question of what we have learned from this approach so far and how these screens contributed towards an integrative understanding of the endomembrane system. The aim of this review is to revisit these screens and discuss their strengths and weaknesses as well as potential reasons for their failure to overlap with each other. As with secretory trafficking, RNAi screens were also performed on other cellular processes such as cell migration and autophagy, both of which were shown to be intimately linked to secretion. Another aim of this review is to compare the outcome of the RNAi screens on secretion, autophagy and cell migration and ask whether the functional genomic approaches have uncovered potential mechanistic insights into the links between these processes.

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Citations

Dec 1, 2015·Frontiers in Neuroscience·Eduardo A Alvarez-MirandaHesso Farhan
Apr 24, 2015·Molecular Biology of the Cell·Valentina MillarteHesso Farhan
Nov 2, 2019·Cellular and Molecular Life Sciences : CMLS·Cecilia A BrunelloHenri J Huttunen
Aug 12, 2017·Biology of the Cell·Inmaculada Ayala, Antonino Colanzi
May 5, 2017·Molecular Biology of the Cell·Hesso FarhanSusan Ferro-Novick
Jun 25, 2019·Developmental Cell·Juliati RahajengSeth J Field

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