Systems genetics: From GWAS to disease pathways

Biochimica Et Biophysica Acta
Marijke R van der SijdeJingyuan Fu

Abstract

Most common diseases are complex, involving multiple genetic and environmental factors and their interactions. In the past decade, genome-wide association studies (GWAS) have successfully identified thousands of genetic variants underlying susceptibility to complex diseases. However, the results from these studies often do not provide evidence on how the variants affect downstream pathways and lead to the disease. Therefore, in the post-GWAS era the greatest challenge lies in combining GWAS findings with additional molecular data to functionally characterize the associations. The advances in various ~omics techniques have made it possible to investigate the effect of risk variants on intermediate molecular levels, such as gene expression, methylation, protein abundance or metabolite levels. As disease aetiology is complex, no single molecular analysis is expected to fully unravel the disease mechanism. Multiple molecular levels can interact and also show plasticity in different physiological conditions, cell types and disease stages. There is therefore a great need for new integrative approaches that can combine data from different molecular levels and can help construct the causal inference from genotype to phenotype. Systems ...Continue Reading

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Jun 22, 2001·Trends in Genetics : TIG·R C Jansen, J P Nap
Mar 30, 2002·Science·Rachel B BremLeonid Kruglyak
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Feb 14, 2004·Bioinformatics·Tim Beissbarth, Terence P Speed
May 24, 2005·Trends in Genetics : TIG·Dirk-Jan de Koning, Chris S Haley
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Andrew R Joyce, Bernhard Ø Palsson
May 9, 2008·PLoS Biology·Eric E SchadtRoger Ulrich
Jul 4, 2008·Trends in Genetics : TIG·Yoav GiladJonathan K Pritchard
Sep 18, 2008·Nature Reviews. Molecular Cell Biology·Guy Karlebach, Ron Shamir
Jan 27, 2009·Nature Genetics·Jingyuan FuRitsert C Jansen
Feb 7, 2009·Current Opinion in Plant Biology·Ritsert C JansenLauren M McIntyre
Feb 24, 2009·Nature Genetics·Julien F AyrolesTrudy F C Mackay
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
Aug 1, 2009·Science·Antigone S DimasStylianos E Antonarakis
Dec 29, 2009·Nature Genetics·Thomas IlligKarsten Suhre
Mar 30, 2010·American Journal of Human Genetics·Hua ZhongEric E Schadt
Jun 26, 2010·The Journal of Clinical Investigation·Xia YangPek Yee Lum
Oct 19, 2010·Trends in Genetics : TIG·Yang LiRitsert C Jansen
Dec 24, 2010·Molecular Systems Biology·Michael InouyeLeena Peltonen
Feb 10, 2011·PLoS Genetics·Alexandra C NicaUNKNOWN MuTHER Consortium
Feb 26, 2011·Science·Joseph H Nadeau, Aimée M Dudley
Mar 10, 2011·Nature Reviews. Genetics·Stephen B Montgomery, Emmanouil T Dermitzakis
Mar 24, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A J WalleyP Froguel
Aug 31, 2011·European Journal of Epidemiology·Albert HofmanJacqueline C M Witteman

❮ Previous
Next ❯

Citations

Jan 20, 2016·Seminars in Cell & Developmental Biology·Iain J GallagherKenneth Fearon
Oct 24, 2014·Journal of Internal Medicine·L MilaniA Metspalu
Mar 27, 2016·Gynecologic Oncology·Guillaume Taglang, David B Jackson
May 3, 2016·Cell Systems·Nigel P S Crawford
May 20, 2014·Biochimica Et Biophysica Acta·Marten H HofkerCisca Wijmenga
Feb 27, 2015·Journal of Human Genetics·Sefayet KaracaRenato Polimanti
Mar 17, 2015·Neuropsychology Review·Lachlan T StrikeMargaret J Wright
Aug 16, 2016·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Liangdan SunLin He
Feb 20, 2015·Biology of Reproduction·Jenny N FungGrant W Montgomery
Nov 3, 2015·Environmental Health Perspectives·Gill LangleyCatherine Willett
Sep 3, 2016·International Journal of Molecular Sciences·Julia WelzenbachChristine Große-Brinkhaus
Nov 18, 2019·Plant, Cell & Environment·Benedict C OyigaAgim Ballvora
Jan 18, 2020·EMBO Molecular Medicine·Annerieke SierksmaMark Fiers
Jun 4, 2019·Equine Veterinary Journal·M E McCue, A M McCoy
Mar 23, 2017·Frontiers in Genetics·Lin ChenSeyed M Moghadas
Nov 1, 2015·Personalized Medicine·Sophie Visvikis-Siest, Maria G Stathopoulou
Oct 24, 2017·Scientific Reports·Tobias EgliAnnette Milnik
Mar 10, 2015·Biochemistry. Biokhimii︠a︡·L I Patrushev, T F Kovalenko
Dec 17, 2020·Frontiers in Veterinary Science·Courtney F PierceTimothy J Smyser
Jun 1, 2021·Studies in History and Philosophy of Science·Jonathan Michael Kaplan, Eric Turkheimer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Related Papers

Current Opinion in Genetics & Development
Naomi R WrayPeter M Visscher
Biochemical and Biophysical Research Communications
Brian D Hobbs, Craig P Hersh
Frontiers in Genetics
B A McKinney, Nicholas M Pajewski
Human Molecular Genetics
Alexandra C Nica, Emmanouil T Dermitzakis
© 2021 Meta ULC. All rights reserved