Most common diseases are complex, involving multiple genetic and environmental factors and their interactions. In the past decade, genome-wide association studies (GWAS) have successfully identified thousands of genetic variants underlying susceptibility to complex diseases. However, the results from these studies often do not provide evidence on how the variants affect downstream pathways and lead to the disease. Therefore, in the post-GWAS era the greatest challenge lies in combining GWAS findings with additional molecular data to functionally characterize the associations. The advances in various ~omics techniques have made it possible to investigate the effect of risk variants on intermediate molecular levels, such as gene expression, methylation, protein abundance or metabolite levels. As disease aetiology is complex, no single molecular analysis is expected to fully unravel the disease mechanism. Multiple molecular levels can interact and also show plasticity in different physiological conditions, cell types and disease stages. There is therefore a great need for new integrative approaches that can combine data from different molecular levels and can help construct the causal inference from genotype to phenotype. Systems ...Continue Reading
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
Coexpression network based on natural variation in human gene expression reveals gene interactions and functions.
Global patterns of cis variation in human cells revealed by high-density allelic expression analysis.
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.
Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals
Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent
Systems Genetic Validation of the SNP-Metabolite Association in Rice Via Metabolite-Pathway-Based Phenome-Wide Association Scans
Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury
Multi-omic data integration and analysis using systems genomics approaches: methods and applications in animal production, health and welfare
Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention
Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat
Integrative Analysis of Metabolomic, Proteomic and Genomic Data to Reveal Functional Pathways and Candidate Genes for Drip Loss in Pigs
Genetic components of root architecture and anatomy adjustments to water-deficit stress in spring barley
Genetic Variation at Chromosome 2q13 and Its Potential Influence on Endometriosis Susceptibility Through Effects on the IL-1 Family
Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects
Genome-Wide Association and Transcriptome Analyses Reveal Candidate Genes Underlying Yield-determining Traits in Brassica napus
A systems genetics approach reveals environment-dependent associations between SNPs, protein coexpression, and drought-related traits in maize.
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