Systems toxicology

ALTEX
Thomas HartungRussell Thomas

Abstract

The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries. Omics technologies provide a valuable opportunity to refine existing methods and provide information for so-called integrated testing strategies via the creation of signatures of toxicity. By mapping these signatures to underlying pathways of toxicity, some of which have been identified by toxicologists over the last few decades, and bringing them together with pathway information determined from biochemistry and molecular biology, a "systems toxicology" approach will enable virtual experiments to be conducted that can improve the prediction of hazard and the assessment of compound toxicity.

Citations

Mar 19, 2013·Archives of Toxicology·Marcel Leist, Thomas Hartung
Mar 5, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bas J BlaauboerJeroen Schuermans
Mar 16, 2016·Toxicological Research·John Michael SauerA Wallace Hayes
Jun 1, 2013·Journal of Applied Toxicology : JAT·Mounir BouhifdLiang Zhao
Aug 12, 2014·Congenital Anomalies·Yuhei NishimuraToshio Tanaka
Jan 22, 2014·Basic & Clinical Pharmacology & Toxicology·Mounir BouhifdThomas Hartung
Jul 9, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·James GigrichThomas Holzer
Sep 11, 2016·Drug Delivery and Translational Research·Seppo RönkköArto Urtti
Oct 11, 2016·Expert Opinion on Drug Metabolism & Toxicology·Thomas Hartung
Apr 1, 2017·Chemical Research in Toxicology·Thomas HartungShana J Sturla
Mar 26, 2015·International Journal of Toxicology·John Michael SauerA Wallace Hayes
Nov 22, 2017·Journal of Nanobiotechnology·Eleonore Fröhlich
Oct 21, 2017·Archives of Toxicology·Marcel LeistJan G Hengstler
Oct 17, 2019·Toxicology Mechanisms and Methods·Chirag N PatelHimanshu A Pandya
Feb 12, 2014·Alternatives to Laboratory Animals : ATLA·Elizabeth K WoehrlingMichael D Coleman
Jan 1, 2020·Applied in Vitro Toxicology·Thomas Hartung
Jan 23, 2014·Chemical Research in Toxicology·Shana J SturlaManuel C Peitsch

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