Abstract
There is little information about change in dyssynchrony with stress or after revascularization. Subjects were recruited to this study if they were referred for revascularization of viable, dysfunctional myocardium. The inclusion criteria were ejection fraction of < or = 35%, sinus rhythm, and QRS duration < or = 120 msec. Tissue Doppler echocardiography with dobutamine stress was performed at baseline and 6 months after revascularization, and dyssynchrony indices (T-sd(c)) were calculated. A total of 25 patients completed a 6-month follow-up. The mean (standard deviation) resting systolic and diastolic T-sd(c) at baseline were 49.3 (18.2) msec and 41.0 (29.4) msec, respectively, with little change during dobutamine stress. After revascularization, there were no significant differences in mean T-sd(c) although there was a modest effect on systolic T-sd(c) at recovery (46.0 [23.1] msec baseline, 34.2 [20.1] msec follow-up, mean difference 11.8 msec, 95% confidence interval 0.3-23.4 msec, P = .046). Resting dyssynchrony in ischemic left ventricular dysfunction does not seem to be altered by dobutamine stress or revascularization.
References
Sep 14, 1999·Journal of the American College of Cardiology·F A ChaudhryR O Bonow
Dec 17, 2002·Heart·C-M YuJ E Sanderson
Jul 11, 2003·Lancet·J G F ClelandA Lahiri
May 4, 2004·European Heart Journal·Stefano GhioLuigi Tavazzi
May 20, 2004·Journal of Cardiovascular Electrophysiology·Gabe B BleekerJeroen J Bax
Oct 29, 2005·The American Journal of Cardiology·Patrizio LancellottiLuc A Piérard
Dec 20, 2005·Journal of the American College of Cardiology·Goo-Yeong ChoYung Lee
Dec 20, 2005·European Heart Journal·Pierre V EnnezatPascal de Groote
Jan 24, 2006·Journal of Cardiovascular Electrophysiology·Katja ZeppenfeldJeroen J Bax
Mar 11, 2006·European Heart Journal·Nathaniel M HawkinsJohn J V McMurray
Mar 29, 2006·Nature Clinical Practice. Cardiovascular Medicine·Gabe B BleekerErnst E van der Wall
Apr 20, 2006·Heart·C-M YuJ W-H Fung
Nov 28, 2006·The American Journal of Cardiology·Malcolm I BurgessThomas H Marwick
Dec 13, 2006·Journal of the American College of Cardiology·Gabe B BleekerJeroen J Bax
Jan 2, 2007·The American Journal of Cardiology·Paweł BuszmanMichał Tendera
Jan 9, 2007·Journal of the American College of Cardiology·Jianwen WangSherif F Nagueh
Jan 9, 2007·Journal of the American College of Cardiology·John E Sanderson
Feb 20, 2007·Journal of the American College of Cardiology·Yasuhiko TakemotoJunichi Yoshikawa
Sep 15, 2007·European Heart Journal·Ze-Zhou Song