Systolic blood pressure and mortality after stroke: too low, no go?

Stroke; a Journal of Cerebral Circulation
Michelle P LinAmytis Towfighi

Abstract

Recent studies suggest a J-shaped association between systolic blood pressure (SBP) and cardiovascular events. The optimal SBP target after stroke remains unknown. We assessed the link between SBP and mortality after stroke. We included adults (≥20 years) with self-reported stroke who participated in the National Health and Nutrition Examination Surveys 1998 to 2004, with mortality assessment in 2006. Baseline SBP was categorized as low to normal (<120 mm Hg), normal (120-140 mm Hg), and high (≥140 mm Hg). Independent relationships between baseline SBP and all-cause and vascular mortality were assessed using Cox proportional hazards. Of 31 126 adult participants, 455 had self-reported stroke and baseline BP readings: 19% had low to normal, 31% had normal, and 50% had high SBP. Two years after assessment, the low to normal SBP group tended to have the highest cumulative all-cause mortality (11.5%), compared with mortality rates of 8.5% and 7.5% in the normal and high SBP groups, respectively. Similar patterns were seen with vascular mortality. After adjusting for covariates, compared with the high SBP group, the low to normal group had higher all-cause mortality (adjusted hazard ratio, 1.96; 95% confidence interval, 1.13-3.39; P...Continue Reading

References

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Citations

Mar 24, 2016·Journal of the Neurological Sciences·Qinqin CaoGelin Xu
Oct 31, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Miaomiao ZhaoJue Li
Dec 8, 2017·Journal of the American Heart Association·Chan Joo LeeSungha Park
Jun 24, 2017·Journal of the American Heart Association·Sung-Chun TangUNKNOWN Taiwan Stroke Registry Investigators
Aug 28, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jie XuYongjun Wang
Feb 16, 2021·JAMA Network Open·Amytis TowfighiUNKNOWN Secondary Stroke Prevention by Uniting Community and Chronic Care Model Teams Early to End Disparities (SUCCEED) Investigato

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