Systolic blood pressure and risk of cardiovascular diseases in type 2 diabetes: an observational study from the Swedish national diabetes register

Journal of Hypertension
J CederholmNDR

Abstract

To estimate risks of fatal/nonfatal coronary heart disease (CHD), stroke and cardiovascular disease (CVD) with SBP in an observational study of patients with type 2 diabetes. Twelve thousand, six hundred and seventy-seven patients aged 30-75 years, treated with antihypertensive drugs, without previous congestive heart failure, followed for 5 years. Risk curves of CHD and stroke increased progressively with higher baseline or updated mean SBP in a Cox model, in all participants, and in two subgroups without (n = 10 304) or with (n = 2373) a history of CVD, with no J-shaped risk curves at low SBP levels. Hazard ratios for CHD and stroke per 10-mmHg increase in updated mean SBP in all participants, adjusting for clinical characteristics and traditional risk factors, were 1.08 (1.04-1.13) and 1.20 (1.13-1.27), P < 0.001. With updated mean SBP of 110-129 mmHg as reference, SBP of at least 140 mmHg showed risk increases of 37% for CHD, 86% for stroke and 44% for CVD (P = 0.001 to <0.001), whereas SBP of 130-139 mmHg showed nonsignificant risk increases for these outcomes. With baseline SBP of 110-129 mmHg, CHD and CVD risks increased with further SBP reduction, hazard ratios were 1.77 and 1.73 (P = 0.002), but decreased considerably ...Continue Reading

References

Mar 29, 2003·Diabetes Care·Soffia GudbjörnsdottirUNKNOWN Steering Committee of the Swedish National Diabetes Register
Nov 5, 2005·Journal of Hypertension·Peter M NilssonUNKNOWN Steering Committee of the National Diabetes Register of Sweden
Apr 2, 2008·The New England Journal of Medicine·UNKNOWN ONTARGET InvestigatorsCraig Anderson
Jul 2, 2008·Diabetes Care·Jan CederholmUNKNOWN Swedish National Diabetes Register
Aug 30, 2008·The New England Journal of Medicine·Salim YusufUNKNOWN PRoFESS Study Group
Jan 8, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·S GudbjörnsdottirUNKNOWN Swedish National Diabetes Register (NDR)
Jun 30, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Peter M NilssonUNKNOWN Swedish National Diabetes Register
Oct 20, 2009·Journal of Hypertension·Giuseppe ManciaUNKNOWN European Society of Hypertension
Mar 17, 2010·The New England Journal of Medicine·William C CushmanFaramarz Ismail-Beigi
Jul 8, 2010·JAMA : the Journal of the American Medical Association·Rhonda M Cooper-DeHoffCarl J Pepine

❮ Previous
Next ❯

Citations

Oct 19, 2011·Journal of General Internal Medicine·Emaad M Abdel-RahmanAlaa S Awad
Dec 20, 2012·Therapeutic Advances in Chronic Disease·Helga GudmundsdottirIngrid Os
Feb 21, 2014·The American Journal of the Medical Sciences·Aidar R GosmanovElvira O Gosmanova
Jul 29, 2011·Journal of Zhejiang University. Science. B·Peter M Nilsson
May 6, 2011·Diabetes Care·Peter M Nilsson, Jan Cederholm
Jul 19, 2016·The American Journal of Medicine·Nanette K WengerUNKNOWN American College of Cardiology Cardiovascular Disease in Women Committee
Nov 10, 2011·Hypertension·Johannes A N DorresteijnUNKNOWN Secondary Manifestations of Arterial Disease Study Group
Jul 7, 2011·Perspectives in Clinical Research·Natasha Das, Monica Panjabi
Jul 11, 2019·Cardiovascular Diabetology·Stefanie Hägg-HolmbergUNKNOWN FinnDiane Study Group
Jun 2, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·J CederholmUNKNOWN Swedish National Diabetes Register
Aug 21, 2014·Postgraduate Medicine·Ahmed H AbdelhafizJose M F de Oliveira
Aug 25, 2018·Open Medicine·Hernando Vargas-Uricoechea, Manuel Felipe Cáceres-Acosta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
Marieke P Hoevenaar-BlomW M M Verschuren
American Journal of Hypertension
John B KostisOPERA Study Group. Omapatrilat in Persons with Enhanced Risk of Atherosclerotic events
Journal of the Renin-angiotensin-aldosterone System : JRAAS
Peter A MeredithLIFE trial
© 2021 Meta ULC. All rights reserved