Systolic blood pressure reduction and risk of acute renal injury in patients with intracerebral hemorrhage

The American Journal of Medicine
Adnan I QureshiAntihypertensive Treatment of Acute Cerebral Hemorrhage Investigators

Abstract

Aggressive systolic blood pressure reduction may precipitate acute renal injury because of underlying hypertensive nephropathy in patients with intracerebral hemorrhage. The study's objective was to determine the rate and determinants of acute renal injury during acute hospitalization among subjects with intracerebral hemorrhage using a post hoc analysis of a multicenter prospective study. Subjects with intracerebral hemorrhage and elevated systolic blood pressure of 170 mm Hg or greater who presented within 6 hours of symptom onset and underwent treatment of acute hypertensive response and fluid management as per study and local protocols, respectively. Acute renal injury was defined post hoc using the criteria used in Acute Kidney Injury Network classifications within 72 hours of admission. Descriptive statistics and standard statistical tests were used to characterize and evaluate the effect of systolic blood pressure reduction parameters (relative to initial systolic blood pressure) and average maximum hourly dose of nicardipine on the occurrence of acute renal injury. A total of 60 subjects were recruited (57% were men; mean age of 62.0 ± 15.1 years). Five subjects (9%) had stage I acute renal injury according to the Acute...Continue Reading

References

Apr 20, 1987·The Medical Journal of Australia·G J Hankey, S S Gubbay
Jan 1, 1967·Neurology·J E Lee, J M Haynes
Mar 1, 1996·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K HayashiT Saruta
Jul 20, 2000·The New England Journal of Medicine·M TepelW Zidek
Apr 12, 2005·Current Opinion in Nephrology and Hypertension·Melanie L Praught, Michael G Shlipak
Jun 29, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Sana JivrajGregory M T Hare
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Aug 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George TsagalisKonstantinos N Vemmos
Aug 30, 2008·Critical Care : the Official Journal of the Critical Care Forum·José António LopesMateus Martins Prata
Nov 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Saeid EslamiAmeen Abu-Hanna
Dec 4, 2008·Neurocritical Care·Gustavo J RodriguezAdnan I Qureshi
May 23, 2009·Stroke; a Journal of Cerebral Circulation·Alexandra OleinikJoshua N Goldstein
Sep 23, 2009·Critical Care Medicine·UNKNOWN Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) investigators
May 18, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bruce OvbiageleJeffrey L Saver

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Citations

Feb 15, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fahad SaeedAdnan I Qureshi
Jul 18, 2014·Lancet Neurology·Kazunori Toyoda, Toshiharu Ninomiya
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tetsuya MiyagiKazunori Toyoda
Feb 6, 2017·Current Opinion in Critical Care·Julian Bösel
Apr 15, 2018·Journal of the American Heart Association·L Goodwin BurgessJason J Chang
Nov 14, 2018·Annals of Neurology·Kazunori ToyodaUNKNOWN ATACH-2 Trial Investigators
Aug 26, 2020·Stroke; a Journal of Cerebral Circulation·Adnan I QureshiUNKNOWN Antihypertensive Treatment of Cerebral Hemorrhage 2 Trial Investigators
Nov 24, 2016·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Wei-Hung LaiHsiao-Yun Hsieh
Nov 12, 2020·The American Journal of Emergency Medicine·Laura TiffanyQuincy K Tran

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