Systolic functional response of normal older and younger adult left ventricles to dobutamine

The American Journal of Cardiology
Z S KyriakidesF Voridis

Abstract

To determine the systolic functional response of the aged left ventricle to catecholamines, 16 healthy, physically active subjects aged 62 to 72 years (group A) and 19 healthy adults aged 18 to 28 years (group B) were evaluated before and during infusion of 8 micrograms/kg/min of dobutamine. Phonocardiograms, electrocardiograms and M-mode echocardiograms were recorded simultaneously with a carotid pulse tracing. End-diastolic dimension and end-systolic pressure remained unchanged in the 2 groups. End-systolic dimension decreased 0.3 cm (p less than 0.001) in group A and 0.5 cm (p less than 0.001) in group B. Fractional shortening increased (p less than 0.001) from 34 +/- 4% to 38 +/- 5% in group A and from 34 +/- 4% to 43 +/- 4% in group B. Mean velocity of circumferential fiber shortening (Vcf) increased 0.6 circ/s (p less than 0.001) in group A and 1 circ/s (p less than 0.001) in group B. End-systolic pressure/dimension ratio increased 3 mm Hg/cm (p less than 0.001) in group A and 8 mm Hg/cm (p less than 0.001) in group B. The changes in end-systolic dimension, fractional shortening, Vcf and end-systolic pressure/dimension ratio were more significant in group B (p less than 0.001). Thus, the left ventricular systolic function...Continue Reading

References

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Citations

Oct 1, 1992·Cardiovascular Drugs and Therapy·Z S KyriakidesP Toutouzas
Apr 1, 1995·Cardiovascular Drugs and Therapy·Z S KyriakidesD T Kremastinos
May 1, 1994·International Journal of Cardiology·Z S KyriakidesD T Kremastinos
Feb 15, 1990·The American Journal of Cardiology·M W Rich, M Imburgia
Jun 5, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Margareta Scharin TängBert Andersson
Nov 1, 1994·Scandinavian Journal of Gastroenterology·T KawasakiM Okuma
Apr 18, 2003·Critical Care Clinics·Ramesh Nagappan, Geoffrey Parkin

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