Systolic pressure variation and pulse pressure variation during modifications of arterial pressure.

Intensive Care Medicine
J C KubitzDaniel A Reuter

Abstract

This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). Prospective study in a university laboratory. Twelve anesthetized and mechanically ventilated pigs. Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine. SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1), p < 0.05, increased vs. decreased arterial pressure], whereas PPV did not change during modifications of arterial pressure. During baseline conditions and decreased afterload, correlation with SVV was good both for SPV (r =0.892 and r = 0.859, respectively) and for PPV (r = 0.870 and r = 0.871, respectively) (all p < 0.001). Correlation with SVV was only moderate during increased arterial pressure (r = 0.683 for SPV and r = 0.732 for PPV, p < 0.05). For guiding fluid therapy in patients under vasopressor support, PPV seems superior to SPV.

References

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Oct 11, 2005·Critical Care Medicine·Michael R Pinsky

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Citations

Jun 18, 2010·Critical Care : the Official Journal of the Critical Care Forum·Jan BenesMartin Stepan
Jun 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Fritz DaudelJukka Takala
Jan 1, 2014·Clinical and Experimental Pharmacology & Physiology·Thomas G V CherpanathJohan A B Groeneveld
Jun 3, 2017·British Journal of Anaesthesia·M I Monge GarcíaM Cecconi
Apr 25, 2020·Frontiers in Physiology·Manuel Ignacio Monge GarcíaMichael R Pinsky

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