Syzyguim guineense Extracts Show Antioxidant Activities and Beneficial Activities on Oxidative Stress Induced by Ferric Chloride in the Liver Homogenate

Antioxidants
Constant Anatole PiemeJeanne Yonkeu Ngogang

Abstract

The aim of this study was to determine the in vitro antioxidant activity, free radical scavenging property and the beneficial effects of extracts of various parts of Syzygium guineense in reducing oxidative stress damage in the liver. The effects of extracts on free radicals were determined on radicals DPPH, ABTS, NO and OH followed by the antioxidant properties using Ferric Reducing Antioxidant Power assay (FRAP) and hosphomolybdenum (PPMB). The phytochemical screening of these extracts was performed by determination of the phenolic content. The oxidative damage inhibition in the liver was determined by measuring malondialdehyde (MDA) as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and peroxidase. Overall, the bark extract of the ethanol/water or methanol showed the highest radical scavenging activities against DPPH, ABTS and OH radicals compared to the other extracts. This extract also contained the highest phenolic content implying the potential contribution of phenolic compounds towards the antioxidant activities. However, the methanol extract of the root demonstrated the highest protective effects of SOD and CAT against ferric chloride while the hydro-ethanol extract of the lea...Continue Reading

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Citations

Sep 21, 2016·Journal of Ethnopharmacology·Thuy Lan NguyenHelle Wangensteen
Oct 28, 2018·Journal of Complementary & Integrative Medicine·Ifeoma C Ezenyi, John O Igoli
May 6, 2015·Journal of Complementary & Integrative Medicine·Bruno Moukette MouketteJeanne Yonkeu Ngogang
Jan 7, 2017·BMC Complementary and Alternative Medicine·Solomon Asmamaw Tadesse, Zewdu Birhanu Wubneh
Aug 31, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jacques Joël EssogoConstant Anatole Pieme
Apr 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Melese AbebeGirma Seyoum

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Methods Mentioned

BETA
Assay
MDA

Software Mentioned

XLstat
SPSS

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