T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-gamma responses

Toxicology and Applied Pharmacology
Maoxiang LiJ J Pestka

Abstract

Trichothecenes are exquisitely toxic to the gastrointestinal (GI) tract and leukocytes and thus are likely to impair gut immunity. The purpose of this research was to test the hypothesis that the Type A trichothecene T-2 toxin interferes with the gut mucosal immune response to enteric reovirus infection. Mice were exposed i.p. first to 1.75 mg/kg bw T-2 and then 2 h later with 3 x 10(7) plaque-forming units of reovirus serotype 1, strain Lang (T1/L). As compared to vehicle-treated control, T-2-treated mice had dramatically elevated intestinal plaque-forming viral titers after 5 days and failed to completely clear the virus from intestine by 10 days. Levels of reovirus lambda2 core spike (L2 gene) RNA in feces in T-2-treated mice were significantly higher at 1, 3, 5, and 7 days than controls. T-2 potentiated L2 mRNA expression in a dose-dependent manner with as little as 50 microg/kg of the toxin having a potentiative effect. T-2 exposure transiently suppressed induction of reovirus-specific IgA in feces (6 and 8 days) as well as specific IgA and IgG2a in serum (5 days). This suppression corresponded to decreased secretion of reovirus-specific IgA and IgG2a in Peyer's patch (PP) and lamina propria fragment cultures prepared 5 da...Continue Reading

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Citations

Sep 11, 2012·Toxicology·Mona AgrawalP V Lakshmana Rao
Sep 29, 2006·Toxicology and Applied Pharmacology·Maoxiang LiJames J Pestka
Jan 17, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mona AgrawalP V Lakshmana Rao
Nov 21, 2017·Archives of Toxicology·Qinghua WuKamil Kuca
Oct 26, 2018·International Journal of Molecular Sciences·Qinghua WuKamil Kuca
Oct 1, 2008·Experimental Biology and Medicine·George N GirgisTrevor K Smith
Sep 30, 2018·Biological Trace Element Research·Zhihua RenJunliang Deng
Oct 29, 2020·Human & Experimental Toxicology·Shafiqur RahmanShahid Prawez
Dec 10, 2020·Toxins·Philippe Guerre
May 15, 2010·Toxicon : Official Journal of the International Society on Toxinology·Marc Maresca, Jacques Fantini

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Methods Mentioned

BETA
ELISA
PCR

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