T and B Cell Immune Responses to Influenza Viruses in Pigs

Frontiers in Immunology
Barbara HolzerElma Tchilian

Abstract

Influenza viruses are an ongoing threat to humans and are endemic in pigs, causing considerable economic losses to farmers. Pigs are also a source of new viruses potentially capable of initiating human pandemics. Many tools including monoclonal antibodies, recombinant cytokines and chemokines, gene probes, tetramers, and inbred pigs allow refined analysis of immune responses against influenza. Recent advances in understanding of the pig innate system indicate that it shares many features with that of humans, although there is a larger gamma delta component. The fine specificity and mechanisms of cross-protective T cell immunity have yet to be fully defined, although it is clear that the local immune response is important. The repertoire of pig antibody response to influenza has not been thoroughly explored. Here we review current understanding of adaptive immune responses against influenza in pigs and the use of the pig as a model to study human disease.

References

Jan 1, 1978·The Journal of Experimental Medicine·M W VerbonitzP Albrecht
Apr 1, 1974·The Journal of Infectious Diseases·R B CouchE D Kilbourne
Jul 7, 1983·The New England Journal of Medicine·A J McMichaelP A Beare
Feb 1, 1995·Veterinary Microbiology·B W LeeM E Larson
May 9, 2000·Veterinary Microbiology·D L LarsenC W Olsen
May 29, 2000·Science·K B ChuaB W Mahy
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V C HuberD W Metzger
Sep 15, 2001·Veterinary Immunology and Immunopathology·P P HeinenA T Bianchi
Mar 15, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kaw Bing Chua
Oct 28, 2004·Journal of Virology·Mikhail N MatrosovichHans-Dieter Klenk
Feb 24, 2009·Nature Structural & Molecular Biology·Jianhua SuiWayne A Marasco
Mar 3, 2009·Science·Damian C EkiertIan A Wilson
Jan 29, 2010·BMC Veterinary Research·Rahul K NelliKin-Chow Chang
Apr 15, 2010·The Journal of Clinical Investigation·Davide CortiAntonio Lanzavecchia
Nov 23, 2010·Expert Review of Vaccines·Suzanne L Epstein, Graeme E Price
Jan 12, 2011·The Journal of Experimental Medicine·Jens WrammertPatrick C Wilson
Jul 9, 2011·Science·Damian C EkiertJaap Goudsmit
Aug 13, 2011·Science·Taia T Wang, Peter Palese
Dec 14, 2011·Trends in Microbiology·François MeurensVolker Gerdts
Mar 23, 2012·Animal Health Research Reviews·Ryan L Vander VeenKurt I Kamrud

❮ Previous
Next ❯

Citations

Dec 18, 2019·Annual Review of Animal Biosciences·Sabine E HammerJoan K Lunney
Aug 28, 2020·Frontiers in Immunology·Gary EntricanJohn A Hammond
Jul 20, 2019·Antiviral Research·Koen Sedeyn, Xavier Saelens
Mar 3, 2021·Porcine Health Management·Hamish A Salvesen, C Bruce A Whitelaw
Jun 3, 2021·Viruses·Cindy M SpruitRobert P de Vries
Jul 31, 2021·Developmental and Comparative Immunology·Lauren Le PageSabine E Hammer

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
ELISA

Software Mentioned

PigMatrix

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.