T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart field

Human Molecular Genetics
Christopher De BonoRobert G Kelly

Abstract

The arterial and venous poles of the mammalian heart are hotspots of congenital heart defects (CHD) such as those observed in 22q11.2 deletion (or DiGeorge) and Holt-Oram syndromes. These regions of the heart are derived from late differentiating cardiac progenitor cells of the Second Heart Field (SHF) located in pharyngeal mesoderm contiguous with the elongating heart tube. The T-box transcription factor Tbx1, encoded by the major 22q11.2 deletion syndrome gene, regulates SHF addition to both cardiac poles from a common progenitor population. Despite the significance of this cellular addition the mechanisms regulating the deployment of common progenitor cells to alternate cardiac poles remain poorly understood. Here we demonstrate that Tbx5, mutated in Holt-Oram syndrome and essential for venous pole development, is activated in Tbx1 expressing cells in the posterior region of the SHF at early stages of heart tube elongation. A subset of the SHF transcriptional program, including Tbx1 expression, is subsequently downregulated in Tbx5 expressing cells, generating a transcriptional boundary between Tbx1-positive arterial pole and Tbx5-positive venous pole progenitor cell populations. We show that normal downregulation of the def...Continue Reading

References

Jun 22, 1999·Developmental Biology·B G BruneauC E Seidman
Jun 23, 2000·Developmental Biology·C M LiberatoreK E Yutzey
Mar 10, 2001·Nature Genetics·L A Jerome, V E Papaioannou
Apr 12, 2001·BMC Developmental Biology·S SrinivasF Costantini
Sep 18, 2003·Development·Tatiana HochgrebJosé Xavier-Neto
Jun 4, 2004·Development·Huansheng XuAntonio Baldini
Mar 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Catherine RobertsPeter J Scambler
Jan 31, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jun MaedaDeepak Srivastava
Jul 18, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Daria CipolloneBruno Marino
Jan 24, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert G Kelly, Virginia E Papaioannou
Jul 5, 2007·Genesis : the Journal of Genetics and Development·Tuong HuynhAntonio Baldini
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lucile RyckebuschKaren Niederreither
Feb 22, 2008·Nature·Benoit G Bruneau
Mar 11, 2008·Developmental Biology·Jun LiaoBernice E Morrow
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ioan Ovidiu SirbuGregg Duester
Jun 28, 2008·Circulation Research·Magali Théveniau-RuissyRobert G Kelly
Apr 17, 2009·Development·Andrew D HoffmannIvan P Moskowitz
Apr 25, 2009·Circulation Research·Francesca RochaisRobert G Kelly
Sep 12, 2009·Circulation Research·Li ChenAntonio Baldini
Oct 20, 2009·Developmental Biology·Laura A Dyer, Margaret L Kirby
May 25, 2010·The American Journal of Cardiology·Kazuo Momma
Oct 22, 2010·The New England Journal of Medicine·Jonathan A Epstein
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mathieu NadeauMona Nemer
Mar 10, 2011·Developmental Biology·Nicolas BertrandStéphane Zaffran
Jun 10, 2011·Development·Ingo BotheSusanne Dietrich
Mar 1, 2012·Human Molecular Genetics·Luna Simona PaneAntonio Baldini
Mar 28, 2012·Current Topics in Developmental Biology·Robert G Kelly
May 1, 2012·Human Molecular Genetics·Scott SmemoMarcelo A Nobrega
Jun 20, 2012·Differentiation; Research in Biological Diversity·Laura E BriggsAndy Wessels
Sep 3, 2013·Current Opinion in Pediatrics·Bruce D Gelb
Apr 29, 2014·Nature Communications·Sonia StefanovicVincent M Christoffels

❮ Previous
Next ❯

Citations

May 8, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert E Poelmann, Adriana C Gittenberger-de Groot
Jun 4, 2019·Journal of Developmental Biology·Eliyahu Perl, Joshua S Waxman
Jun 11, 2019·Human Molecular Genetics·Daniela AlfanoAntonio Baldini
Dec 11, 2019·Cold Spring Harbor Perspectives in Biology·Benjamin Swedlund, Fabienne Lescroart
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ségolène Bernheim, Sigolène M Meilhac
Jan 15, 2020·Cold Spring Harbor Perspectives in Biology·Vincent Christoffels, Bjarke Jensen
Feb 13, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Marieke F J BuijtendijkMaurice J B van den Hoff
Feb 13, 2021·Journal of Cardiovascular Development and Disease·Kendall E Martin, Joshua S Waxman
Nov 8, 2020·Journal of Cardiovascular Development and Disease·Ray DeepeAndy Wessels
Jan 25, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Ioan Ovidiu SirbuAlexander Radu Moise
Apr 4, 2021·Genes·Tingsen Benson LimChing Kit Chen
May 1, 2021·Journal of Cardiovascular Development and Disease·Sonia StefanovicStéphane Zaffran
Jun 10, 2021·Nature Communications·Jacinta I Kalisch-SmithDuncan B Sparrow
Aug 8, 2021·International Journal of Molecular Sciences·Lauren Michelle WalkerNicole I Zur Nieden
Jun 2, 2021·Annual Review of Genomics and Human Genetics·Lucile Houyel, Sigolène M Meilhac

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.