T-cadherin gene variants are associated with nephropathy in subjects with type 1 diabetes

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Anthony NicolasF Fumeron

Abstract

High plasma adiponectin levels are associated with diabetic nephropathy (DN). T-cadherin gene (CDH13) variants have been shown to be associated with adiponectin levels. We investigated associations between allelic variations of CDH13 and DN in subjects with type 1 diabetes. Two CDH13 polymorphisms were analysed in 1297 Caucasian subjects with type 1 diabetes from the 'Survival Genetic Nephropathy' (SURGENE) (n = 340, 10-year follow-up), 'Genesis France-Belgium' (GENESIS) (n = 501, 5-year follow-up for n = 462) and 'Génétique de la Néphropathie Diabétique' (GENEDIAB) (n = 456, 9-year follow-up for n = 283) cohorts. Adiponectin levels were measured in plasma samples from GENESIS and GENEDIAB cohorts. Pooled analysis of GENEDIAB and GENESIS studies showed that baseline plasma adiponectin levels were higher in subjects with established/advanced DN at inclusion (P < 0.0001) and in subjects who developed end-stage renal disease (ESRD) at follow-up (P < 0.0001). The minor allele of rs3865188 was associated with lower adiponectin levels (P = 0.006). rs11646213 [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.18-1.85; P = 0.0009] and rs3865188 (OR 0.71; 95% CI 0.57-0.90; P = 0.004) were associated with baseline prevalence of establ...Continue Reading

References

May 20, 1999·American Journal of Human Genetics·X XuZ Fang
Dec 12, 2001·Biochemistry. Biokhimii︠a︡·D B IvanovV A Tkachuk
Oct 18, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N Stefan, M Stumvoll
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher HugHarvey F Lodish
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Helen C LookerRobert L Hanson
May 28, 2005·Diabetes Care·Markku SaraheimoUNKNOWN FinnDiane study group
Sep 1, 2005·Virchows Archiv : an International Journal of Pathology·Joachim ArnemannWiltrud Coerdt
Oct 13, 2005·The Journal of Clinical Endocrinology and Metabolism·Casper G SchalkwijkUNKNOWN EURODIAB Prospective Complications Study Group
Mar 18, 2006·Human Molecular Genetics·Jordana Tzenova BellMartin Farrall
Jul 5, 2006·Clinical Endocrinology·Harpal S RandevaPaul O'Hare
Dec 6, 2006·The American Journal of Cardiology·Yoshio IwashimaToshio Ogihara
Sep 18, 2007·Medical Molecular Morphology·Tamotsu TakeuchiMutsuo Furihata
Oct 6, 2007·The Journal of Clinical Hypertension·Yuichiro YanoKazuomi Kario
Oct 3, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Kaire HeilmanVallo Tillmann
Apr 29, 2009·Cellular Signalling·Maria PhilippovaTherese J Resink
Jan 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Riphed JaziriUNKNOWN DIABHYCAR and SURDIAGENE Study Groups
Nov 3, 2010·The Journal of Clinical Investigation·Martin S DenzelBarbara Ranscht
Aug 30, 2011·The American Journal of Cardiology·Cristiano FavaOlle Melander
Oct 3, 2012·PLoS Genetics·Niina SandholmAlexander P Maxwell
Jul 5, 2013·The Journal of Biological Chemistry·Jennifer L Parker-DuffenKenneth Walsh
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Natalie Sweiss, Kumar Sharma
Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Jennifer L Parker-Duffen, Kenneth Walsh
Apr 18, 2014·The New England Journal of Medicine·Edward W GreggLinda Geiss
Oct 26, 2014·European Heart Journal. Acute Cardiovascular Care·Dennis PfaffMaria Philippova
Oct 16, 2015·PloS One·Lorena Ortega MorenoClaudia Menzaghi

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