T-cadinol and calamenene induce dendritic cells from human monocytes and drive Th1 polarization

European Journal of Pharmacology
Masao TakeiShigenobu Arihara

Abstract

T-cadinol and calamenene are sesquiterpenes isolated from the heartwood of Cryptomeria japonica and are pharmacologically active substances. Dendritic cells are pivotal in the initiation of adaptive immune responses and are recognized as key to the induction of immune responses to cancer. This study investigated the effects of T-cadinol and calamenene on the phenotypic and functional maturation of human monocyte-derived dendritic cells in vitro. Human monocytes were cultured with recombinant human granulocyte-macrophage colony-stimulation factor (GM-CSF) and recombinant human interleukin-4 (IL-4) for 6 days under standard conditions, followed by another 2 days in the presence of T-cadinol, calamenene, lipopolysaccharide (LPS), CT or nifedipine. Dendritic cells harvested on day 8 were examined using functional assays. The expression levels of CD1a, CD80, CD83, CD86 and HLA-DR on T-cadinol-primed dendritic cells or calamenene-primed dendritic cells were enhanced with a concomitant decrease in endocytic activity. T-cadinol-primed dendritic cells or calamenene-primed dendritic cells also enhanced the T cell stimulatory capacity in an allogeneic mixed lymphocyte reaction, as measured by T cell proliferation. Naïve T cells co-culture...Continue Reading

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Citations

Jun 30, 2010·Journal of Natural Medicines·Akemi UmeyamaToshihiro Hashimoto
Jun 5, 2010·Biological & Pharmaceutical Bulletin·Hironori YoshinoIkuo Kashiwakura
Nov 28, 2009·European Journal of Pharmacology·Masao TakeiToshihiro Hashimoto
Mar 13, 2008·Biochemical and Biophysical Research Communications·Masao TakeiToshihiro Hashimoto
Oct 31, 2014·Integrative Cancer Therapies·Shang-Tse HoJyh-Horng Wu
Oct 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joshua MorimotoAlbert Robbat
Jun 16, 2011·Chemistry & Biodiversity·Hilla TamirNativ Dudai

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