T cell- and B cell-independent adaptive immunity mediated by natural killer cells.

Nature Immunology
Jacqueline G O'LearyUlrich H von Andrian

Abstract

It is commonly believed that only T lymphocytes and B lymphocytes expressing recombination-dependent antigen-specific receptors mediate contact hypersensitivity responses to haptens. Here we found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone. Those responses were adaptive in nature, as they persisted for at least 4 weeks and were elicited only by haptens to which mice were previously sensitized. No contact hypersensitivity was induced in mice lacking all lymphocytes, including natural killer cells. Contact hypersensitivity responses were acquired by such mice after adoptive transfer of natural killer cells from sensitized donors. Transferable hapten-specific memory resided in a Ly49C-I(+) natural killer subpopulation localized specifically in donor livers. These observations indicate that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells.

References

Mar 19, 1987·Nature·U HochgeschwenderJ T Epplen
Dec 1, 1996·The Journal of Experimental Medicine·M D CatalinaM H Siegelman
Nov 25, 1998·British Journal of Haematology·J P GoldmanA J Thrasher
Dec 3, 1999·The British Journal of Dermatology·R E HungerC U Brand
Dec 10, 1999·The New England Journal of Medicine·C Robert, T S Kupper
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Jun 8, 2001·The Journal of Experimental Medicine·P D RennertY X Fu
Jan 24, 2002·The Journal of Clinical Investigation·Stephan GrabbeKarin Scharffetter-Kochanek
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
May 2, 2002·Cell·Craig H BassingFrederick W Alt
Dec 24, 2002·Nature Immunology·Daniel M AndrewsMariapia A Degli-Esposti
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong ZhaoMegan Sykes
Jul 4, 2003·Nature·J Rodrigo MoraUlrich H Von Andrian
Sep 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Marie CumberbatchIan Kimber
Oct 3, 2003·Nature Reviews. Immunology·David H Raulet
Oct 22, 2003·The Journal of Experimental Medicine·Eckart SchottHidde L Ploegh
Jan 28, 2004·Cell·David Jung, Frederick W Alt
Sep 10, 2004·Current Molecular Medicine·M A Morris, K Ley
Oct 12, 2004·Genomics·Marie-France ProteauAndrew P Makrigiannis
Nov 9, 2004·Nature Immunology·Alfonso Martín-FontechaFederica Sallusto
Feb 3, 2005·Nature Reviews. Immunology·Mariapia A Degli-Esposti, Mark J Smyth
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Mar 31, 2005·Trends in Immunology·Joachim Kurtz
Apr 1, 2005·PLoS Biology·Frederic GeissmannDan R Littman

❮ Previous
Next ❯

Citations

Jun 10, 2011·Cancer Immunology, Immunotherapy : CII·Anil Shanker, Francesco M Marincola
Mar 19, 2013·Trends in Immunology·Gundula Min-OoLewis L Lanier
May 4, 2013·Trends in Immunology·Daniel B Graham, Ramnik J Xavier
Sep 24, 2013·Trends in Immunology·Jianhua YuMichael A Caligiuri
Jul 25, 2013·Journal of Autoimmunity·Kelly HudspethDomenico Mavilio
Apr 9, 2013·Cellular & Molecular Immunology·Xiaojun JiangZhigang Tian
Mar 18, 2009·Immunology and Cell Biology·Michal Pyzik, Silvia M Vidal
Dec 22, 2010·Immunology and Cell Biology·Joseph C Sun, Lewis L Lanier
Apr 5, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael P BlundellAdrian J Thrasher
Jan 13, 2009·Nature·Joseph C SunLewis L Lanier
Jul 9, 2011·Nature Immunology·Silke Paust, Ulrich H von Andrian
Aug 21, 2012·Nature Immunology·Natalie A BezmanUNKNOWN Immunological Genome Project Consortium
Apr 20, 2006·Nature Immunology·Wayne M Yokoyama
Nov 17, 2010·Nature Immunology·Christine A Biron
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Apr 22, 2008·Nature Immunology·Wayne M Yokoyama
Apr 28, 2009·Nature Reviews. Immunology·Lewis L Lanier, Joseph C Sun
Feb 26, 2011·Nature Reviews. Immunology·Marcus AltfeldNina Bhardwaj
Sep 24, 2011·Nature Reviews. Immunology·Fu-Dong ShiLuc Van Kaer
Jan 14, 2012·Nature Reviews. Immunology·Daniel H KaplanAnthony A Gaspari
Jul 16, 2009·Médecine sciences : M/S·Nadège Bercovici, Anne Caignard
May 18, 2007·The New England Journal of Medicine·Margaret I Johnston, Anthony S Fauci
Aug 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rui HeRaif S Geha
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Severine Le BrasRaif S Geha
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yongjun SuiJay A Berzofsky
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandra Lopez-VergèsLewis L Lanier
Oct 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Emilie Narni-MancinelliEric Vivier
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Johanneke KleinnijenhuisMihai G Netea
Mar 21, 2007·The Journal of Experimental Medicine·Martin A SchneiderAntal Rot
Jul 9, 2008·The Journal of Experimental Medicine·Joseph C Sun, Lewis L Lanier
Jan 26, 2011·The Journal of Experimental Medicine·Joseph C SunLewis L Lanier
Dec 22, 2010·The Journal of Experimental Medicine·Niklas K BjörkströmHans-Gustaf Ljunggren
Dec 15, 2010·The Journal of Experimental Medicine·Zhenghui LiuRodger P McEver
Apr 12, 2012·The Journal of Experimental Medicine·Joseph C SunLewis L Lanier
Dec 5, 2012·The Journal of Experimental Medicine·Jing NiAdelheid Cerwenka
May 8, 2013·The Journal of Experimental Medicine·Georg GasteigerAlexander Y Rudensky
Nov 28, 2013·The Journal of Experimental Medicine·Matthew A FirthJoseph C Sun
Jun 27, 2012·Brain : a Journal of Neurology·Gurman KaurLars Fugger
Jun 15, 2011·International Immunology·Emilie Narni-MancinelliYann M Kerdiles
Jul 12, 2012·AIDS·Vivek NaranbhaiUNKNOWN Centre for the AIDS Programme of Research in South Africa (CAPRISA) Tenofovir gel Research for AIDS Prevention Science (TRAP
Oct 18, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sylvia Cremer, Michael Sixt
May 2, 2012·TheScientificWorldJournal·Hamid ShegarfiAbbas Mirshafiey
Jan 8, 2011·Science·Eric VivierSophie Ugolini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Megan A CooperWayne M Yokoyama
Proceedings of the National Academy of Sciences of the United States of America
Sandra Lopez-VergèsLewis L Lanier
© 2022 Meta ULC. All rights reserved