T cell activation defect in hemodialysis patients: evidence for a role of the B7/CD28 pathway

Kidney International
M GirndtB Fleischer

Abstract

The immunosuppressive effect of chronic renal failure is correlated with an impaired proliferation of peripheral blood leukocytes in vitro. This is mainly due to an impaired function of the accessory cells rather than the T cells. Here we tried to define a missing accessory signal for T cell activation in hemodialysis patients. We substituted cell surface bound molecules by adding tumor cell lines to the in vitro assays that express different patterns of accessory molecules. Cell lines that express the costimulatory B7 molecule reconstituted the activation of patients' cells whereas B7 negative cells did not. The reconstitution was also achieved using mouse fibroblasts transfected with human B7 or by monoclonal antibodies that stimulate the B7 ligand CD28 on T cells. These data further emphasize that impaired leukocyte function in renal failure is due to an accessory cell defect, and that T cells of these patients have normal functional capacities when they get the costimulatory signals required. We demonstrate that it is the B7/CD28 pathway that reconstitutes cellular functions in the patients.(ABSTRACT TRUNCATED AT 250 WORDS)

References

Dec 1, 1992·European Journal of Immunology·M de BoerJ Reeder
Dec 1, 1992·The Journal of Experimental Medicine·P S LinsleyN K Damle
Jun 1, 1992·Current Opinion in Immunology·Y Liu, P S Linsley
Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Jun 15, 1990·Science·R H Schwartz
Jul 1, 1990·Clinical Immunology and Immunopathology·R A GibbonsM R Garovoy
Jun 1, 1986·Kidney International·P KurzK H Meyer zum Büschenfelde

❮ Previous
Next ❯

Citations

Apr 26, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R U PliquettJ Beige
Mar 14, 2012·Nature Reviews. Nephrology·Gunnar H HeineUNKNOWN European Renal and Cardiovascular Medicine (EURECA‑m) working group of the European Renal Association-European Dialysis and
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M GirndtH Köhler
Sep 28, 2007·Seminars in Dialysis·Theodoros EleftheriadisIoannis Stefanidis
Nov 11, 2003·Clinical and Diagnostic Laboratory Immunology·Patricia AguilarAnne Kennel De March
May 24, 2012·Experimental & Molecular Medicine·Kyoung Woon KimChul Woo Yang
Feb 13, 2001·Kidney International. Supplement·M GirndtH Köhler
Jan 6, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M GirndtH Köhler
Apr 28, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M GirndtH Köhler
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S KrügerB Kreft
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H KaulH Köhler
Sep 11, 2007·Infectious Disease Clinics of North America·Robert N Foley
Oct 25, 2012·Thrombosis and Haemostasis·Jörn F DopheideChristine Espinola-Klein
Feb 26, 2005·Clinical and Experimental Immunology·P-T BrinkkoetterB A Yard
Sep 30, 2005·Hemodialysis International·Sydney Tang, Kar Neng Lai
Apr 21, 2009·FEMS Immunology and Medical Microbiology·Maysaa el-Sayed ZakiAly F Mohamed
Apr 27, 2007·European Journal of Immunology·Odelia KatzDrorit Neumann
Dec 25, 2009·Renal Failure·Mohammad Mahdi SaghebGolmehr Sajjady
Aug 24, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Paul L KimmelPaul W Eggers
Aug 20, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·James Diskin, Charles J Diskin
Dec 4, 2019·The Cochrane Database of Systematic Reviews·Patrizia NataleGiovanni Fm Strippoli
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·O SchreinerE Märker-Hermann
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·U SesterM Girndt
Jul 7, 2017·Immune Network·Ji Ung KimHyunwoo Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.