Jun 18, 2011

T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers

AIDS Research and Therapy
Philomena KamyaNicole F Bernard

Abstract

Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment. Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38+HLA-DR+CD8+ T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls. Compared to HIV uninfected subjects, EC had higher percentages of CD38+HLA-DR+CD8+ T cells (p < 0.001) that was lower than that observed in progressors (p < 0.01). Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets with stable/increasing versus declining CD4 counts. Elevated immune activation in ECs is not associated with a faster rate of CD4 decline.

Mentioned in this Paper

Immune System
T-Lymphocyte
Dimethyl Sulfoxide
Virus Replication
Bos taurus
HIV Infections
CD38 gene
CD4 Count Determination Procedure
Viremia
T-Cell Activation

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