PMID: 7547688Apr 1, 1995Paper

T cell activation through Thy-1 is associated with the expression of a surface protein (p100) on a subset of CD4 cells

International Immunology
A LehuenR C Monteiro

Abstract

Thy-1 molecules, which lack a transmembrane domain, can nonetheless induce T cell activation; it has thus been suggested that a separate transmembrane molecule associated with Thy-1 is required for signal transduction. We have previously characterized a transmembrane protein with an Mr of 100,000 (p100), which is non-covalently bound to two glycosyl-phosphatidylinositol (GPI)-linked molecules, Thy-1 and ThB. p100 is selectively expressed on the T cell surface and divides peripheral CD4 cells into two subpopulations. This differential expression on CD4 cells allowed us to investigate the role of p100 in signal transduction through Thy-1 molecules. Here we report that only p100+ CD4 cells proliferate and release cytokines in response to cross-linkage of Thy-1, although both p100+ and p100- CD4 cells strongly express Thy-1 on their surfaces. Control stimulation by anti-CD3 antibodies or concanavalin A induces identical thymidine uptake by the two CD4 cell populations. Interestingly, these two populations of CD4 cells had different cytokine release profiles after activation through CD3: only p100+ CD4 cells released high amounts of IL-2 and IFN-gamma, whereas both populations released IL-4. p100 expression correlates with the induc...Continue Reading

Citations

Jun 1, 1997·Journal of Neuroscience Research·N KaiT Yagi
Jan 19, 2000·Immunology Today·S IlangumaranD C Hoessli
Jul 7, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S YokochiK Matsushima
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M Mansour Haeryfar, David W Hoskin

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