PMID: 8942393Nov 1, 1996Paper

T-cell autoimmunity in primary biliary cirrhosis

Clinical Science
D E Jones

Abstract

1. Primary biliary cirrhosis is a chronic cholestatic liver disease with an autoimmune aetiology. The classical histopathological lesion, of portal tract biliary epithelial cell damage, is accompanied by a T-cell-rich mononuclear cell infiltrate and upregulation of cell surface markers suggestive of local T-cell activation and cytokine release. This suggests that T-cell mediated mechanisms play an important role in tissue damage in primary biliary cirrhosis. 2. CD4+ T-cells specific for the E2 component of human pyruvate dehydrogenase complex (PDC-E2), a highly conserved enzyme which plays a critical role in intermediate metabolism, are present in the peripheral repertoire of the majority of patients with primary biliary cirrhosis. These cells are almost entirely absent from normal and chronic liver disease control subjects. The observations that peripheral blood PDC-E2-specific cells are most commonly seen in early stage disease, when active bile duct damage is occurring, and that PDC-E2- specific cells can be found in the portal tract infiltrate at times when this damage is occurring, suggest that these autoreactive cells may have a role to play in the aetiology of primary biliary cirrhosis. 3. T-cells specific for the whole ...Continue Reading

Citations

May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J MayoP E Lipsky
Oct 6, 1997·Lancet·J Neuberger
Apr 27, 2000·Journal of Hepatology·K AgarwalM F Bassendine
Oct 17, 2001·Annals of the Rheumatic Diseases·B MarasiniP Ferrari
May 9, 2006·The Journal of Biological Chemistry·Michaela SmolleJohn Gordon Lindsay
May 25, 2007·Virus Research·Nemat Sokhandan BashirMohammad Saeid Hejazi
Mar 10, 2001·Clinics in Liver Disease·C L Mabee, D L Thiele
Feb 13, 2001·European Journal of Clinical Investigation·J MedinaR Moreno-Otero
Apr 21, 1999·Clinical and Experimental Immunology·J M PalmerD E Jones
Jan 24, 2021·NPJ Systems Biology and Applications·Bhanwar Lal PuniyaTomáš Helikar
Apr 7, 2010·Journal of Molecular Biology·S VijayakrishnanO Byron

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