PMID: 15240682Jul 9, 2004Paper

T cell biasing by activated dendritic cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Charles F AndersonDavid M Mosser

Abstract

We have previously reported that the ligation of FcgammaRs on activated macrophages affected their production of cytokines and their ability to influence T cell activation. Dendritic cells (DC) are important APCs that also express FcgammaR. In the present work, we sought to determine whether DC responded to immune complexes in a manner similar to macrophages. We confirmed that activated murine DC produced IL-12, and, as a result, induced naive T cells to produce primarily IFN-gamma upon stimulation. However, DC activated in the presence of immune complexes shut off their production of IL-12p70 and induced a Th2-like cytokine response. Thus, DC respond to immune complexes by altering their cytokine production, which, in turn, influences T cell responses. A DC transfer experiment was performed to determine the extent that APC exposure to immune complexes could influence adaptive immune responses. Vaccination of mice with Ag, along with DC that were activated in the presence of immune complexes, resulted in higher levels of Ag-specific IgG1 Ab, relative to mice that were vaccinated with activated DC and Ag alone. The mechanism by which DC altered their cytokine production in response to immune complexes was different from macropha...Continue Reading

References

Dec 1, 1986·Experimental Parasitology·D M MosserP J Edelson
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R A SederW E Paul
Oct 31, 1996·Nature·A K AbbasA Sher
Jun 2, 1997·The Journal of Experimental Medicine·F S SutterwalaD M Mosser
Apr 1, 1998·European Journal of Immunology·O L WijburgN van Rooijen
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Jul 7, 1998·The Journal of Experimental Medicine·F S SutterwalaD M Mosser
Oct 2, 1998·Advances in Immunology·G Trinchieri
Jan 20, 1999·The Journal of Experimental Medicine·H S JunJ W Yoon
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W ZouT J Curiel
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A T KamathK Shortman
Sep 8, 2001·Nature Immunology·M SchnareR Medzhitov
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danita H SchuurhuisFerry Ossendorp
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles F Anderson, David M Mosser
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine SedlikSebastian Amigorena
Jan 30, 2003·Journal of Leukocyte Biology·David M Mosser

❮ Previous
Next ❯

Citations

May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deirdre Thomas-RudolphCarolyn Mold
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diego A Vargas-InchausteguiLynn Soong
Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·Omid Akbari, Dale T Umetsu
Nov 21, 2007·Journal of Clinical Immunology·Shee Eun LeeJoon Haeng Rhee
Aug 1, 2007·The Journal of Experimental Medicine·Hozefa S BandukwalaAnne I Sperling
Mar 18, 2011·European Journal of Immunology·Nicole JollerAnnette Oxenius
Mar 16, 2016·PloS One·Ceren CiraciSuzanne L Cassel
Mar 9, 2005·The Journal of Experimental Medicine·Suzanne A MilesDavid M Mosser
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dharmesh D DesaiRaphael Clynes
Dec 25, 2008·Annual Review of Immunology·Fernando O MartinezSiamon Gordon
Jan 21, 2011·Theoretical Biology & Medical Modelling·Virginia A FolcikClay B Marsh
Sep 29, 2007·Theoretical Biology & Medical Modelling·Virginia A FolcikCharles G Orosz
Dec 6, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Graham Pockley, Brian Henderson
Jan 22, 2005·Current Allergy and Asthma Reports·Omid Akbari, Dale T Umetsu
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·John L PrehnStephan R Targan
Jul 21, 2010·Nature Immunology·Bali PulendranSanthakumar Manicassamy
Sep 20, 2008·PLoS Pathogens·Amanda C StanleyChristian R Engwerda
Jun 25, 2015·Microbiology Spectrum·Scott B Halstead

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Charles F Anderson, David M Mosser
Journal of Endotoxin Research
Charles F AndersonDavid M Mosser
© 2022 Meta ULC. All rights reserved