PMID: 6170716Nov 1, 1981Paper

T cell clones reactive with sperm whale myoglobin. Isolation of clones with specificity for individual determinants on myoglobin

The Journal of Experimental Medicine
A J InfanteC G Fathman

Abstract

We have been able to isolate clones of sperm whale muscle myoglobin (Mb)-reactive T cells from (C57BL/6 x A/J)F1 [(B6A)F1] mice. Four types of clones were isolated, distinguished by their patterns of recognition of Mb cyanogen bromide (CNBr) fragments and antigen presenting cell (APC) requirements. Individual T cell clones proliferated in response to one of three CNBr fragments of Mb. Dose-response curves of all clones were identical for native Mb and the appropriate fragment. T cell clones reactive to fragment 1-55 did not proliferate in response to peptide 15-22 (a peptide that binds to serum antibody directed against 1-55). These data support previous findings suggesting differences between antigen recognition by T and B cells, i.e., T cells may not recognize antigen in its native conformation and/or T and B cells may recognize distinct epitopes on the same antigen. Using T cell clones to analyze genetic control of responsiveness to Mb, we found that certain (B6A)F1 T cells recognize Mb presented by low responder strain APC. Thus, genetically determined low responsiveness in this case is probably not due to failure of APC function. We also found that responsiveness to certain Mb epitopes mapped to the I-A subregion whereas o...Continue Reading

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J A BerzofskyD J Killion
Sep 1, 1979·European Journal of Immunology·A A AugustinH Cosenza
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C G Fathman, H Hengartner
Apr 13, 1978·Nature·C G Fathman, H Hengartner
Oct 1, 1980·The Journal of Experimental Medicine·E A LernerD B Murphy
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C G FathmanC S David
Jan 1, 1980·Immunological Reviews·G KelsoeK Rajewsky

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Citations

Jul 1, 1983·Molecular Immunology·G CorradinH D Engers
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E Bikoff
Oct 1, 1982·The Journal of Experimental Medicine·B N BeckC G Fathman
Jun 1, 1986·The Journal of Experimental Medicine·K H MillsD B Thomas
Jul 1, 1991·The Journal of Experimental Medicine·G RubertiA M Livingstone
Mar 1, 1985·Scandinavian Journal of Immunology·E QvigstadH Hirschberg
Jan 1, 1986·Microbiology and Immunology·M Kimoto, C G Fathman
Mar 1, 1992·Cellular Immunology·Z NovakB Singh

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