T-Cell co-stimulation by the CD28 ligand B7 is involved in the immune response leading to rejection of a spontaneously regressive tumor

International Journal of Cancer. Journal International Du Cancer
P ChauxF Martin

Abstract

Cell variants from experimental tumors may lose their tumorigenicity or give rise to tumors that regress after a short period of progression in immunocompetent syngeneic animals. Rejection of these tumor cells is often T-cell-dependent. It has recently been reported that, besides the specific signal delivered through the clonogenic receptor, T-cell activation requires a co-stimulatory signal, delivered through its CD28 receptor by B7-1 and/or B7-2 molecules expressed at the surface of the antigen-presenting cells. CTLA4Ig, a fusion molecule that specifically inhibits B7-1 and B7-2 binding to their receptors of T cells, was used to investigate the role of B7 in the spontaneous regression of the tumors induced in syngeneic rats by REGb cells, a regressor cell line established from a chemically induced colon carcinoma. When rats received either 1 or 3 CTLA4Ig injections, REGb tumors grew 3 or 7 times larger than in control animals, respectively. However, in most animals, single or repeated CTLA4Ig injections delayed rather than suppressed REGb tumor rejection. Antibodies to CTLA4Ig appeared in treated rats and could explain this transient effect. Neither REGb cells nor freshly isolated MHC class-II+ antigen-presenting cells infilt...Continue Reading

References

Apr 1, 1975·Pathology·V J McGovern
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L A TurkaD Gordon
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·A CaignardF Martin
Jul 1, 1982·The Journal of Experimental Medicine·W E KlinkertW E Bowers
Jan 1, 1983·Advances in Cancer Research·T Boon
Nov 1, 1994·The Journal of Experimental Medicine·V A BoussiotisL M Nadler
Jun 1, 1993·Current Opinion in Immunology·M K Jenkins, J G Johnson
Jan 28, 1994·Cell·C A Janeway, K Bottomly
Feb 20, 1993·International Journal of Cancer. Journal International Du Cancer·D ReisserF Martin

❮ Previous
Next ❯

Citations

Oct 31, 2002·Immunology and Cell Biology·Scott N Byrne, Gary M Halliday
Jun 1, 1997·Expert Opinion on Investigational Drugs·G YangL Chen
May 23, 2001·Leukemia·V F Van TendelooZ N Berneman
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BonnotteF Martin
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Khanh Nguyen, Bonnie C Miller
Mar 3, 2020·Cellular Immunology·Yuting ChenFaming Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.