T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction.

Journal of the American Society of Nephrology : JASN
M H Sayegh, L A Turka

Abstract

It is now accepted that T cells need two signals for full activation. The first is the foreign antigen itself presented by self-major histocompatibility complex and thus provides antigen specificity to the immune response. The second is a "costimulatory" signal, the best-characterized of which is provided through the T cell accessory molecule CD28. In vitro, the blockade of costimulatory signals inhibits T cell activation and induces a state of antigen-specific unresponsiveness. In vivo, agents that block CD28-mediated costimulation have proved extremely effective in inhibiting the immune response in experimental models of transplantation and autoimmune disease, providing novel strategies for use in clinical trials in the near future.

Citations

Jun 11, 1999·Journal of the American Society of Nephrology : JASN·H Gudmundsdottir, L A Turka
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·W W HancockL A Turka
Sep 2, 1998·Transplantation Proceedings·X G Zheng, L A Turka
Jan 19, 2000·Immunology Today·R M Smith, T E Mandel
Jan 5, 2002·Journal of the American Academy of Dermatology·James G Krueger
Jun 26, 2002·Kidney International·Roslyn B MannonThomas M Coffman
May 20, 2003·Immunological Reviews·Elise ChiffoleauLaurence Turka
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Barbara MurphyMohamed H Sayegh
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nora FranceschiniRoslyn B Mannon
Jan 22, 2005·Immunology and Cell Biology·Yanina DitamoGerman A Roth
Nov 23, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P N Rocha, E M Carvalho
Dec 21, 2006·Clinical and Experimental Immunology·S SharmaJ N Agrewala
Jan 4, 1998·Kidney International·A ChandrakerM H Sayegh
Jan 4, 1998·Kidney International·T M Coffman
Aug 2, 2007·Expert Opinion on Biological Therapy·Massimo Trucco, Nick Giannoukakis
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vissia Viglietta, Samia J Khoury
Feb 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Wen-Hui ZhouDa-Jin Li
Feb 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M R First
Jun 11, 2008·Pediatric Diabetes·Nick GiannoukakisMassimo Trucco
Jun 24, 2008·Annales pharmaceutiques françaises·A Hulin
Jul 1, 1997·Postgraduate Medical Journal·J P Vella, M H Sayegh
May 19, 2010·Expert Review of Clinical Immunology·Brett PhillipsMassimo Trucco
Apr 23, 2009·Transplantation·Anja Reutzel-SelkeJohann Pratschke
Nov 28, 2017·Current Opinion in Organ Transplantation·Ivica Grgic, Anil Chandraker
Dec 30, 1999·International Reviews of Immunology·S KhouryL A Turka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.