T-cell cytokines may control the balance of functionally distinct macrophage populations

Immunology
V J TormeyL W Poulter

Abstract

As monocytes differentiate into mature macrophages, subsets emerge that exhibit stimulatory, suppressive or phagocytic potential. These functionally distinct subsets can be discriminated using monoclonal antibodies RFD1 and RFD7. As examples of all these subsets have been repeatedly identified within the macrophage pool in a variety of organs the overall functional capacity of this pool will depend on the relative balance of these subpopulations. This study investigates whether this balance present in mature macrophage populations can be regulated by the local influence of T-cell-derived cytokines. The dose-dependent effect of cytokines interferon-gamma (IFN-gamma), interleukins (IL) IL-2, IL-4 and IL-10 on the phenotype and function of monocyte-derived macrophages was determined. Subsets of mature cells were quantified by identifying RFD1- RFD7- stimulatory cells (D1+); RFD1- RFD7+ phagocytes (D7+) and RFD1+ RFD7+ suppressive cells (D1 D7+). IFN-gamma and IL-4 increased the relative proportions of D1+ stimulatory cells and upregulated HLA-DR expression. IFN-gamma also increased the capacity of the mature macrophage pool to stimulate T-cell proliferation. IL-10 reduced the proportions of D1+ stimulatory cells while promoting th...Continue Reading

References

Dec 1, 1992·FEMS Microbiology Immunology·C Hutter, L W Poulter
May 1, 1988·Journal of Clinical Pathology·P M KellyJ O McGee
Mar 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F Belardelli
Jun 1, 1995·Current Opinion in Immunology·T M Doherty
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·L ZhengU Costabel
May 28, 1994·Annals of the New York Academy of Sciences·T ThepenP G Holt
Oct 1, 1996·Immunobiology·L W Poulter, C M Burke

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Citations

May 24, 2003·Biochemical and Biophysical Research Communications·Svetlana N RadyukKen Alibek
Mar 11, 2000·Disease-a-month : DM·P R Liebson, E A Amsterdam
May 22, 1998·Transplantation Proceedings·H SchorlemmerR Kurrle
Oct 2, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V J TormeyL W Poulter
Dec 22, 1999·Clinical and Experimental Immunology·V J TormeyL W Poulter
Jan 14, 1999·The New England Journal of Medicine·R Ross
May 20, 2000·Annals of the New York Academy of Sciences·V O EmeryJ A Smith
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·C T LeonardG D Rosen
Sep 6, 2007·The Journal of Clinical Investigation·Lisa C ZabaMichelle A Lowes
Jan 27, 1998·Environmental Health Perspectives·A HolianL Li
Oct 26, 2002·Annals of the Royal College of Surgeons of England·Charles Maxwell-Armstrong
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·R S Rosenson
Jul 29, 2008·International Journal of Cardiology·Jessica M LambertMerry L Lindsey
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Claire E Routley, Gillian S Ashcroft
Mar 12, 2005·Journal of the Neurological Sciences·V Olga EmeryJoseph A Smith
Dec 7, 2000·The American Journal of Pathology·M M SantosM W Schilham
Oct 16, 2013·Atherosclerosis·D F van Breukelen-van der StoepM Castro Cabezas
Mar 4, 2020·International Journal of Molecular Sciences·Subhradip MukhopadhyayRajabrata Sarkar
Dec 21, 2007·Clinical and Vaccine Immunology : CVI·Betsey E PottsStephen K Chapes

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