PMID: 6966402Mar 1, 1980Paper

T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level

Proceedings of the National Academy of Sciences of the United States of America
J AnderssonF Melchers

Abstract

Cloned lines of helper thymus-derived (T) cells produce help for bone marrow-derived (B) cell growth and Ig secretion in the presence of histocompatible adherent cells and of specific antigen. This help stimulates histocompatible as well as histoincompatible B-cell blasts polyclonally. Thus, neither antigen nor histocompatibility, but antigen-unspecific factor(s) for growth and Ig secretion are required to stimulate a B-cell blast through the next round of division. On the other hand, only histocompatible, resting, small B cells, and only those binding their specific antigen, can be stimulated by antigen-activated T-cell help to initiate growth and Ig secretion. The preference of the resting B cells for such collaboration with T-cell help is mapped to the K end of the H-2 histocompatibility locus, and probably constitutes the antigen expressed on B cells by the immune response (I) region. It appears that a resting B cell is excited by the binding of specific antigen to surface Ig and by the interaction of its surface Ia antigen with helper T cells. After this dual recognition the excited B cell can be stimulated by the antigen-unspecific factor(s) generated by the interaction of helper T-cells, adherent cells, and antigen to in...Continue Reading

References

Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Mar 1, 1979·The Journal of Experimental Medicine·J AnderssonF Melchers
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D H KatzB Benacerraf
Jun 8, 1973·Nature·H Waldmann, A Munro
Jun 1, 1969·Journal of Cellular Physiology·R G Miller, R A Phillips
Jan 1, 1980·The Journal of Experimental Medicine·M H SchreierF Melchers

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Citations

Nov 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·M G AgadzhanianE V Sidorova
Jul 1, 1988·Journal of Clinical Immunology·S J AndersonA R Lawton
Nov 1, 1993·Journal of Clinical Immunology·M K SpriggsJ Belmont
Aug 1, 1980·Springer Seminars in Immunopathology·J SprentK Molnar-Kimber
Jan 1, 1986·Springer Seminars in Immunopathology·R H ZublerP A Miescher
Jan 1, 1988·Immunologic Research·J G Monroe, V L Seyfert
Jan 1, 1980·Journal of Immunological Methods·A Altman, D H Katz
Oct 1, 1990·Immunology Today·R J Noelle, E C Snow
May 1, 1990·Research in Immunology·E C SnowK E Pollok
May 1, 1990·Research in Immunology·L S Marshall, R J Noelle
May 1, 1990·Research in Immunology·M K Crow, S M Friedman
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J Anderson, F Melchers
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E C DeFreitasC M Croce
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M H JuliusC L Sidman
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J NoelleE S Vitetta
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L LeclercqJ Thèze
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N J LoCascioR B Corley
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R B CorleyG Haughton
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F Melchers, W Lernhardt
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N HaradaT Honjo
Mar 1, 1982·The Journal of Experimental Medicine·P C IsaksonP H Krammer
May 1, 1982·The Journal of Experimental Medicine·A L DefrancoW E Paul
Mar 1, 1984·The Journal of Experimental Medicine·A L DeFrancoW E Paul
Jul 1, 1984·The Journal of Experimental Medicine·D E Mosier, A J Feeney
Sep 1, 1984·The Journal of Experimental Medicine·N W RoehmJ C Cambier

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