Abstract
T-cell-depleted, haploidentical transplantations (haplos) are commonly offered to patients who have high-risk, acute leukemia in the absence of a human leukocyte antigen (HLA) full-matched donor. To determine the effect of transplantation period, the authors divided 308 adults with de novo, acute leukemia who underwent T-cell-depleted haplo from 2005 to 2015 into 2 groups, according the year in which they underwent transplantation (2005-2011 [n = 191] and 2012-2015 [n = 117]). The median age was 41 years in patients who underwent transplantation before 2012 and 46 years in those who underwent transplantation after 2012 (P = .04). Most patients had acute myeloid leukemia (75% vs 69%; P = .26) and were in first complete remission (CR1) (55% vs 64%; P = .12) at the time of transplantation. The cumulative incidence of grade 2, 3, and 4 acute graft-versus-host disease (GvHD) and chronic GvHD were not different between the 2 groups (acute GvHD: 20% vs 22% cumulative incidence in patients who underwent haplo before and after 2012, respectively [P = .67]; chronic GvHD: 19% vs 11% cumulative incidence, respectively; P = .12]. The 2-year relapse incidence was 20%, the nonrelapse mortality (NRM) rate was 48%, and no difference was observe...Continue Reading
References
Oct 22, 1998·The New England Journal of Medicine·F AversaM F Martelli
Mar 16, 2002·Science·Loredana RuggeriAndrea Velardi
Apr 30, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephanie J LeeMary E D Flowers
Oct 22, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J F LacerdaJ M F Lacerda
Mar 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Franco AversaMassimo F Martelli
Mar 23, 2006·Blood·Christoph SchmidHans-Jochem Kolb
Oct 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Liang-Piu KohNelson J Chao
Jul 9, 2008·Blood·Fabio CiceriUNKNOWN Acute Leukemia Working Party (ALWP) of European Blood and Marrow Transplant (EBMT) Group
Feb 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sergio GiraltBrenda Sandmaier
Apr 7, 2009·The Lancet Oncology·Fabio CiceriClaudio Bordignon
Aug 12, 2009·Bone Marrow Transplantation·S O CiureaJ Gajewski
Dec 31, 2009·Blood·Thomas KlingebielUNKNOWN Pediatric Diseases and Acute Leukemia Working Parties of the European Group for Blood and Marrow Transplantation (EBMT)
Nov 26, 2010·The New England Journal of Medicine·Ted A GooleyGeorge B McDonald
Apr 12, 2012·Haematologica·Birgit FedermannWolfgang A Bethge
Dec 5, 2012·Seminars in Oncology·Jean-Philippe BastienDenis Claude Roy
Aug 22, 2015·Leukemia·O RingdénM Mohty
Dec 15, 2015·Bone Marrow Transplantation·A RuggeriA Nagler
Dec 31, 2015·Journal of Translational Medicine·Jiangying LiuXiao-Jun Huang
Feb 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jane ApperleyYoshihisa Kodera
Mar 17, 2016·Journal of Hematology & Oncology·Marie T RubioArnon Nagler
Mar 14, 2017·Bone Marrow Transplantation·J R PasswegM Mohty
Jun 8, 2017·Blood·Franco LocatelliLorenzo Moretta
Citations
Oct 24, 2018·Blood·Alice BertainaFranco Locatelli
Oct 26, 2018·Annual Review of Medicine·Christina Cho, Miguel-Angel Perales
Aug 23, 2019·Bone Marrow Transplantation·Arnon Nagler, Annalisa Ruggeri
Aug 2, 2018·Annals of Hematology·Corina SchneidawindDominik Schneidawind
Dec 13, 2019·Frontiers in Immunology·Franco AversaAndrea Velardi
May 18, 2020·Journal of Hematology & Oncology·Meng LvXiao-Jun Huang
Nov 28, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meng LvXiao-Jun Huang
Oct 9, 2021·Frontiers in Immunology·Chao HongXiao-Ming Gao